NCAN and GDF1

Data Source:
BioGRID (biochemical)

		NCAN	GDF1
Description		neurocan	growth differentiation factor 1
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Extracellular Region Golgi Lumen Extracellular Matrix Lysosomal Lumen	Extracellular Space
	Molecular Function	Calcium Ion Binding Hyaluronic Acid Binding Carbohydrate Binding	Cytokine Activity Growth Factor Activity
	Biological Process	Skeletal System Development Cell Adhesion Central Nervous System Development Extracellular Matrix Organization Chondroitin Sulfate Biosynthetic Process Chondroitin Sulfate Catabolic Process Dermatan Sulfate Biosynthetic Process	Positive Regulation Of Pathway-restricted SMAD Protein Phosphorylation BMP Signaling Pathway SMAD Protein Signal Transduction
Pathways		A tetrasaccharide linker sequence is required for GAG synthesis Chondroitin sulfate biosynthesis Dermatan sulfate biosynthesis CS/DS degradation ECM proteoglycans Defective B4GALT7 causes EDS, progeroid type Defective B3GAT3 causes JDSSDHD Defective CHST3 causes SEDCJD Defective CHST14 causes EDS, musculocontractural type Defective CHSY1 causes TPBS L1CAM interactions NCAM1 interactions Defective B3GALT6 causes EDSP2 and SEMDJL1	Signaling by NODAL
Drugs		Beta-D-Glucose Thiodigalactoside Hyaluronic acid
Diseases			Conotruncal heart malformations, including: Double-outlet right ventricle; Persistent truncus arteriosus; Conotruncal anomaly face syndrome Tetralogy of Fallot
GWAS		Bipolar disorder ( 24618891 31043756 21353194) Bipolar I disorder ( 31043756) Bipolar II disorder ( 31043756) Brain morphology (MOSTest) ( 32665545) C-reactive protein levels or LDL-cholesterol levels (pleiotropy) ( 27286809) C-reactive protein levels or total cholesterol levels (pleiotropy) ( 27286809) Cholesterol, total ( 19060911 26780889) LDL cholesterol ( 18193043 19060906 19060911 26780889) Nonalcoholic fatty liver disease ( 29385134) Plateletcrit ( 32888494) Refractive error ( 32231278) Schizophrenia ( 25056061 29483656 23974872) Triglycerides ( 18193043 19060906 19060911)
Interacting Genes		8 interacting genes: CNTN2 HMGB1 L1CAM NCAM1 PTN PTPRF TNC TNR	1 interacting genes: HTR4
Entrez ID		1463	2657
HPRD ID		02897	04194
Ensembl ID		ENSG00000130287	ENSG00000130283
Uniprot IDs		A0A024R7M3 O14594 Q4LE67	A0A024R7N8 P27539
PDB IDs
Enriched GO Terms of Interacting Partners?
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