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CSNK2A1 and DDX3X
Data Source:
BioGRID
(enzymatic study)
CSNK2A1
DDX3X
Description
casein kinase 2 alpha 1
DEAD-box helicase 3 X-linked
Image
GO Annotations
Cellular Component
Nucleus
Nucleoplasm
Cytosol
Plasma Membrane
Protein Kinase CK2 Complex
Sin3 Complex
NuRD Complex
PcG Protein Complex
Extracellular Region
Nucleus
Nucleoplasm
Cytoplasm
Centrosome
Cytosol
Eukaryotic Translation Initiation Factor 3 Complex
Plasma Membrane
Cytoplasmic Stress Granule
Cytosolic Small Ribosomal Subunit
Lamellipodium
Cell Leading Edge
Secretory Granule Lumen
P Granule
Extracellular Exosome
NLRP3 Inflammasome Complex
Ficolin-1-rich Granule Lumen
Molecular Function
Protein Serine/threonine Kinase Activity
Protein Binding
ATP Binding
Kinase Activity
Identical Protein Binding
Protein N-terminus Binding
Hsp90 Protein Binding
Protein Serine Kinase Activity
Protein Threonine Kinase Activity
DNA Binding
DNA Helicase Activity
RNA Binding
RNA Helicase Activity
MRNA Binding
GTPase Activity
Protein Binding
ATP Binding
Transcription Factor Binding
Poly(A) Binding
Eukaryotic Initiation Factor 4E Binding
ATPase Activity
Nucleoside-triphosphatase Activity
Translation Initiation Factor Binding
RNA Strand Annealing Activity
RNA Stem-loop Binding
Gamma-tubulin Binding
Ribosomal Small Subunit Binding
CTPase Activity
Protein Serine/threonine Kinase Activator Activity
Cadherin Binding
MRNA 5'-UTR Binding
Biological Process
Protein Folding
Protein Phosphorylation
Phosphatidylcholine Biosynthetic Process
Apoptotic Process
Cell Cycle
Signal Transduction
Positive Regulation Of Cell Population Proliferation
Wnt Signaling Pathway
Macroautophagy
Peptidyl-serine Phosphorylation
Peptidyl-threonine Phosphorylation
Positive Regulation Of Wnt Signaling Pathway
Positive Regulation Of Cell Growth
Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process
Positive Regulation Of Protein Catabolic Process
Rhythmic Process
Regulation Of Cell Cycle
Chaperone-mediated Protein Folding
Regulation Of Signal Transduction By P53 Class Mediator
Regulation Of Chromosome Separation
Negative Regulation Of Ubiquitin-dependent Protein Catabolic Process
Negative Regulation Of Apoptotic Signaling Pathway
Translational Initiation
Chromosome Segregation
Gamete Generation
Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors
Response To Virus
RNA Secondary Structure Unwinding
Positive Regulation Of Gene Expression
Viral Process
Wnt Signaling Pathway
Negative Regulation Of Translation
Cell Differentiation
Positive Regulation Of Cell Growth
Negative Regulation Of Cell Growth
Negative Regulation Of Protein-containing Complex Assembly
Positive Regulation Of Protein Autophosphorylation
DNA Duplex Unwinding
Positive Regulation Of Interferon-alpha Production
Positive Regulation Of Interferon-beta Production
Stress Granule Assembly
Positive Regulation Of Toll-like Receptor 7 Signaling Pathway
Positive Regulation Of Toll-like Receptor 8 Signaling Pathway
Intracellular Signal Transduction
Positive Regulation Of Translation In Response To Endoplasmic Reticulum Stress
Mature Ribosome Assembly
Positive Regulation Of Apoptotic Process
Negative Regulation Of Apoptotic Process
Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process
Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process
Neutrophil Degranulation
Positive Regulation Of Viral Genome Replication
Innate Immune Response
Positive Regulation Of Translation
Positive Regulation Of Transcription By RNA Polymerase II
Positive Regulation Of Translational Initiation
Lipid Homeostasis
Cellular Response To Arsenic-containing Substance
Cellular Response To Osmotic Stress
Positive Regulation Of Chemokine (C-C Motif) Ligand 5 Production
Positive Regulation Of Protein Serine/threonine Kinase Activity
Positive Regulation Of Canonical Wnt Signaling Pathway
Intrinsic Apoptotic Signaling Pathway
Cellular Response To Virus
Positive Regulation Of G1/S Transition Of Mitotic Cell Cycle
Positive Regulation Of NLRP3 Inflammasome Complex Assembly
Negative Regulation Of NIK/NF-kappaB Signaling
Positive Regulation Of NIK/NF-kappaB Signaling
Positive Regulation Of Protein Acetylation
Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors
Positive Regulation Of Protein K63-linked Ubiquitination
Protein Localization To Cytoplasmic Stress Granule
Negative Regulation Of Intrinsic Apoptotic Signaling Pathway
Pathways
Synthesis of PC
WNT mediated activation of DVL
Condensation of Prometaphase Chromosomes
Signal transduction by L1
Regulation of TP53 Activity through Phosphorylation
Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding
Receptor Mediated Mitophagy
RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known
Regulation of PTEN stability and activity
Neutrophil degranulation
Drugs
ATP
(5-hydroxyindolo[1,2-a]quinazolin-7-yl)acetic acid
1,8-Di-Hydroxy-4-Nitro-Xanthen-9-One
Resveratrol
1,8-Di-Hydroxy-4-Nitro-Anthraquinone
Benzamidine
5,8-Di-Amino-1,4-Dihydroxy-Anthraquinone
Quercetin
Phosphoaminophosphonic Acid-Adenylate Ester
Tetrabromo-2-Benzotriazole
DIMETHYL-(4,5,6,7-TETRABROMO-1H-BENZOIMIDAZOL-2-YL)-AMINE
S-METHYL-4,5,6,7-TETRABROMO-BENZIMIDAZOLE
N1,N2-ETHYLENE-2-METHYLAMINO-4,5,6,7-TETRABROMO-BENZIMIDAZOLE
Emodin
3,8-DIBROMO-7-HYDROXY-4-METHYL-2H-CHROMEN-2-ONE
19-(cyclopropylamino)-4,6,7,15-tetrahydro-5H-16,1-(azenometheno)-10,14-(metheno)pyrazolo[4,3-o][1,3,9]triazacyclohexadecin-8(9H)-one
N,N'-DIPHENYLPYRAZOLO[1,5-A][1,3,5]TRIAZINE-2,4-DIAMINE
4-(2-(1H-IMIDAZOL-4-YL)ETHYLAMINO)-2-(PHENYLAMINO)PYRAZOLO[1,5-A][1,3,5]TRIAZINE-8-CARBONITRILE
2-(CYCLOHEXYLMETHYLAMINO)-4-(PHENYLAMINO)PYRAZOLO[1,5-A][1,3,5]TRIAZINE-8-CARBONITRILE
2-(4-CHLOROBENZYLAMINO)-4-(PHENYLAMINO)PYRAZOLO[1,5-A][1,3,5]TRIAZINE-8-CARBONITRILE
2-(4-ETHYLPIPERAZIN-1-YL)-4-(PHENYLAMINO)PYRAZOLO[1,5-A][1,3,5]TRIAZINE-8-CARBONITRILE
N-(3-(8-CYANO-4-(PHENYLAMINO)PYRAZOLO[1,5-A][1,3,5]TRIAZIN-2-YLAMINO)PHENYL)ACETAMIDE
Dichlororibofuranosylbenzimidazole
Quinalizarin
Ellagic acid
Fostamatinib
Diseases
GWAS
Night sleep phenotypes (
27126917
)
Pursuit maintenance gain (
29064472
)
Refractive error (
32231278
)
Interacting Genes
435 interacting genes:
-
ABCA1
ABCC1
ACACA
ACAT2
ACE
ACIN1
AIP
AKAP8
AKT1
ALKBH5
ANP32B
APEX1
APOE
APP
AQP4
ARL6IP4
ARMCX3
ARNT
ARR3
ARRB2
ASIC3
ATF1
ATF2
ATG16L1
ATN1
ATP2B1
ATP5F1A
AUTS2
BCLAF1
BDP1
BEND7
BHLHE41
BID
BIRC6
BMS1
BRCA1
BRF1
BRMS1
C1orf109
C1orf35
C1R
CALM1
CALU
CANX
CARD9
CASP2
CASQ2
CAV1
CAV2
CCDC116
CCDC6
CD2BP2
CD5
CDC25B
CDC37
CDH1
CDK1
CDKN1A
CFDP1
CHD4
CHUK
CIRBP
CLASP2
CLNS1A
CLTB
COPS2
COPS3
COPS7A
CPSF6
CPSF7
CREB3L3
CREBBP
CREM
CSN1S1
CSN2
CSNK2B
CT45A1
CTDP1
CTNNA1
CTNNB1
CUX2
DAXX
DDIT3
DDX17
DDX21
DDX24
DDX3X
DDX54
DEK
DELEC1
DHX16
DHX38
DKC1
DNAJB2
DPF3
DTD1
DVL1
DVL3
ECD
EEF1B2
EEF1D
EGR1
EHMT2
EIF2B5
EIF2S1
EIF2S2
EIF3J
EIF4B
EIF4EBP1
EIF5
EIF5B
ERH
EXOSC9
F11R
F5
FAF1
FAM133A
FBXO28
FCHO1
FGF1
FGF2
FIBP
FIP1L1
FKBP3
FKBP4
FLG
FNBP4
FOS
FTSJ3
FXR1
GABRR1
GABRR2
GANAB
GAP43
GGA1
GMFB
GMNN
GPATCH2
GPATCH2L
GPI
GPN1
GSC2
GTF2A1
GTF2A1L
GTF2F1
GYS1
HCLS1
HDAC1
HDAC2
HDAC3
HDGFL2
HDLBP
HES6
HGS
HIF1A
HIRIP3
HMGA1
HMGA2
HMOX2
HNRNPA2B1
HNRNPC
HNRNPDL
HNRNPL
HOXB7
HOXC4
HSF1
HSP90AA1
HSP90AB1
HSP90B1
HSPA4
HSPB8
HSPH1
HTATSF1
IFI16
IFRD1
IGF2R
IGFBP3
IL16
INF2
IRF2
IRS1
ITCH
IWS1
JADE2
JUN
KANK2
KDM1A
KEAP1
KIF1C
KIF24
KIF5C
KLF1
KPNA4
L1CAM
LARP1
LEO1
LGALS3
LHX3
LHX8
LHX9
LIG1
LRRC59
LSM14A
LTV1
MAF1
MAGEA11
MAK16
MAPK1
MAPK14
MAPT
MAX
MAZ
MCM2
MCM3
MDC1
MDM2
MEF2C
MEOX1
MEOX2
MFAP1
MGMT
MME
MPHOSPH10
MRPL38
MRPL4
MS4A1
MSH6
MTDH
MUS81
MYB
MYC
MYCN
MYF5
MYH9
NAF1
NAP1L1
NAP1L4
NCAPD2
NCL
NCOR1
NFKBIA
NFKBIB
NFYA
NKX2-5
NMD3
NMT1
NOL3
NOLC1
NOP56
NOP58
NPM1
NRF1
NUP98
NXF1
OCLN
OGDHL
OGT
OSBP
OTUB1
PACS1
PAFAH1B1
PAK1
PAX5
PAX6
PAX7
PDAP1
PDCD4
PDIA6
PGK1
PGR
PHF19
PIAS1
PIN1
PIN4
PIP4K2B
PLEKHO1
PML
PNN
POLR2A
POU6F2
PPAN
PPP1R1B
PPP1R2
PPP1R8
PRCC
PRKACB
PRNP
PRPF38A
PSEN2
PSIP1
PSMA3
PSMA4
PSME3IP1
PTEN
PTPA
PTPN1
PTPRC
PURB
RAD1
RAD51
RAD9A
RANGAP1
RBM10
RBM17
RBM33
RBM39
RBMX
REL
RELA
RGS19
RIOK1
RIOK2
RNF111
RNF7
RPL13
RPL5
RPL6
RPLP0
RPLP1
RPRD2
RPS18
RPS3
RPS6KB1
RRAD
RRP12
RRP1B
RRP9
RSF1
RSL1D1
SAFB
SAP30BP
SAT1
SCNN1A
SEPTIN2
SERBP1
SERPINF1
SF3A1
SF3B1
SF3B2
SFPQ
SHOX
SLC18A2
SLC4A1AP
SLIRP
SMARCC2
SNAI2
SNCA
SND1
SP1
SPATS2L
SPI1
SPIB
SPP1
SPTBN1
SQSTM1
SREK1
SRF
SRRM1
SRRM2
SRRT
SRSF10
SRSF11
SRSF2
SSB
SSRP1
STAC3
STMN1
STX1A
SUB1
SUDS3
SUGT1
SUPT5H
SUPT6H
SURF6
TCF7L2
TCOF1
TEPSIN
TFAP2A
TH
THAP1
THOC5
THRAP3
TLE5
TMOD3
TMPO
TNKS1BP1
TNP1
TOP1
TOP2A
TP53
TP63
TP73
TRIM41
TSPY1
TSPYL2
UBAC1
UBE2D3
UBE2R2
UBTF
USP24
USP48
USP7
UTP14A
UTP18
VAMP4
VDR
VHL
VTN
WAS
WDR44
WDR55
WEE1
XK
XKRY
XRCC1
XRCC4
XRCC5
XRCC6
XRN2
YBX1
YWHAB
YWHAQ
ZC3H13
ZC3H15
ZC3H8
ZFC3H1
ZHX1
ZNF177
ZNF440
ZNF558
ZNF559-ZNF177
ZNF670
ZRANB2
ZSCAN25
92 interacting genes:
APBB1
CSNK2A1
DUX4
ESR1
HNF4A
IKBKE
IL7R
LINC01554
MAVS
MIR1-1
MIR1-2
MIR106A
MIR106B
MIR107
MIR10B
MIR122
MIR128-1
MIR128-2
MIR138-1
MIR138-2
MIR140
MIR141
MIR143
MIR145
MIR155
MIR15A
MIR15B
MIR16-1
MIR16-2
MIR17
MIR18A
MIR18B
MIR199A1
MIR199A2
MIR19A
MIR19B1
MIR19B2
MIR200A
MIR200B
MIR200C
MIR205
MIR206
MIR20A
MIR20B
MIR21
MIR214
MIR221
MIR222
MIR25
MIR29A
MIR29B1
MIR29B2
MIR29C
MIR31
MIR34A
MIR34B
MIR34C
MIR363
MIR429
MIR451A
MIR7-1
MIR7-2
MIR7-3
MIR9-1
MIR9-2
MIR9-3
MIR92A1
MIR92A2
MIR93
MIR98
MIRLET7A1
MIRLET7A2
MIRLET7A3
MIRLET7B
MIRLET7C
MIRLET7D
MIRLET7E
MIRLET7F1
MIRLET7F2
MIRLET7G
MIRLET7I
NEDD4
NFKB2
NUP62
PIN1
SREK1
SRPK2
SUMO2
WBP4
XPO1
YWHAQ
ZNF512B
Entrez ID
1457
1654
HPRD ID
00277
02154
Ensembl ID
ENSG00000101266
ENSG00000215301
Uniprot IDs
P68400
A0A2R8Y7T2
A0A2R8YFS5
O00571
PDB IDs
1JWH
1NA7
1PJK
2PVR
2ZJW
3AMY
3AT2
3AT3
3AT4
3AXW
3BQC
3C13
3FWQ
3H30
3JUH
3MB6
3MB7
3NGA
3NSZ
3OWJ
3OWK
3OWL
3PE1
3PE2
3PE4
3Q04
3Q9W
3Q9X
3Q9Y
3Q9Z
3QA0
3R0T
3RPS
3TAX
3U4U
3U87
3U9C
3W8L
3WAR
3WIK
3WIL
3WOW
4DGL
4FBX
4GRB
4GUB
4GYW
4GYY
4GZ3
4IB5
4KWP
4MD7
4MD8
4MD9
4NH1
4RLL
4UB7
4UBA
5B0X
5CLP
5CQU
5CQW
5CS6
5CSH
5CSP
5CSV
5CT0
5CTP
5CU0
5CU2
5CU3
5CU4
5CU6
5CVF
5CVG
5CVH
5CX9
5H8B
5H8E
5H8G
5HGV
5KU8
5KWH
5M44
5M4C
5M4F
5M4I
5MMF
5MMR
5MO5
5MO6
5MO7
5MO8
5MOD
5MOE
5MOH
5MOT
5MOV
5MOW
5MP8
5MPJ
5N1V
5N9K
5N9L
5N9N
5NQC
5OMY
5ONI
5OQU
5ORH
5ORJ
5ORK
5OS7
5OS8
5OSL
5OSP
5OSR
5OSU
5OSZ
5OT5
5OT6
5OTD
5OTH
5OTI
5OTL
5OTO
5OTP
5OTQ
5OTR
5OTS
5OTY
5OTZ
5OUE
5OUL
5OUM
5OUU
5OWH
5OWL
5OYF
5T1H
5VIE
5VIF
5ZN0
5ZN1
5ZN2
5ZN3
5ZN4
5ZN5
6A1C
6E37
6EHK
6EHU
6EII
6FVF
6FVG
6GIH
6GMD
6HBN
6HME
6HNW
6HNY
6HOP
6HOQ
6HOR
6HOT
6HOU
6JWA
6L1Z
6L21
6L22
6L24
6Q38
6Q4Q
6QY7
6RB1
6RCB
6RCM
6RFE
6RFF
6SPW
6SPX
6TEI
6YPG
6YPH
6YPJ
6YPK
6YPN
6YUL
6YUM
6Z83
6Z84
2I4I
2JGN
3JRV
4O2C
4O2E
4O2F
4PX9
4PXA
5E7I
5E7J
5E7M
6CZ5
6O5F
Enriched GO Terms of Interacting Partners
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