RDH12 and ADCY2

Data Source:
BioGRID (two hybrid)

		RDH12	ADCY2
Description		retinol dehydrogenase 12	adenylate cyclase 2
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Photoreceptor Inner Segment Endoplasmic Reticulum Membrane Photoreceptor Inner Segment Membrane	Cytoplasm Plasma Membrane Integral Component Of Plasma Membrane Membrane Dendrite Membrane Raft
	Molecular Function	Retinol Dehydrogenase Activity Protein Binding NADP-retinol Dehydrogenase Activity	Magnesium Ion Binding Adenylate Cyclase Activity ATP Binding Adenylate Cyclase Binding Manganese Ion Binding
	Biological Process	Retinoid Metabolic Process Visual Perception Retinol Metabolic Process Photoreceptor Cell Maintenance Cellular Detoxification Of Aldehyde	Renal Water Homeostasis CAMP Biosynthetic Process G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Activation Of Adenylate Cyclase Activity Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway CAMP-mediated Signaling Activation Of Protein Kinase A Activity Cellular Response To Glucagon Stimulus Cellular Response To Forskolin
Pathways		Retinoid cycle disease events The canonical retinoid cycle in rods (twilight vision)	Glucagon signaling in metabolic regulation PKA activation PKA activation in glucagon signalling Adenylate cyclase activating pathway Adenylate cyclase inhibitory pathway Adenylate cyclase inhibitory pathway G alpha (s) signalling events G alpha (s) signalling events G alpha (i) signalling events G alpha (z) signalling events G alpha (z) signalling events Vasopressin regulates renal water homeostasis via Aquaporins Hedgehog 'off' state ADORA2B mediated anti-inflammatory cytokines production ADORA2B mediated anti-inflammatory cytokines production FCGR3A-mediated IL10 synthesis
Drugs		Vitamin A	Colforsin 2',5'-DIDEOXY-ADENOSINE 3'-MONOPHOSPHATE Aurothioglucose
Diseases		Leber congenital amaurosis (LCR)
GWAS			Anxiety and stress-related disorders ( 31116379) Atorvastatin-induced myopathy ( 31220337) Bipolar disorder ( 24618891 31043756) Bipolar disorder (age of onset <21) or attention deficit hyperactivity disorder ( 27890468) Bipolar disorder or attention deficit hyperactivity disorder ( 27890468) Bipolar I disorder ( 31043756) Capecitabine sensitivity ( 22864933) Coffee consumption ( 31046077) Cognitive decline rate in late mild cognitive impairment ( 26252872) Food addiction ( 27106561) Mean arterial pressure (alcohol consumption interaction) ( 24376456) Oropharynx cancer ( 27749845) Pars opercularis volume ( 31530798) Plasma factor VII activating protease levels ( 30070759) Posterior-cingulate cortex volume ( 31530798) Smoking status (heavy vs never) ( 26423011) Visceral fat ( 22589738)
Interacting Genes		5 interacting genes: ANXA8L1 BUB1 MAP1LC3A PLEKHA7 RBPMS	6 interacting genes: ADCY1 ADCY5 DRD4 F2RL1 GNAS GNG2
Entrez ID		145226	108
HPRD ID		10585	00052
Ensembl ID		ENSG00000139988	ENSG00000078295
Uniprot IDs		A0A0S2Z613 Q96NR8	Q08462 Q71UM8
PDB IDs
Enriched GO Terms of Interacting Partners?
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