PRICKLE1 and CECR2

Data Source:
BioGRID (affinity chromatography technology)

		PRICKLE1	CECR2
Description		prickle planar cell polarity protein 1	CECR2 histone acetyl-lysine reader
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Cytosol Nuclear Membrane	Nucleus CERF Complex
	Molecular Function	Protein Binding Zinc Ion Binding
	Biological Process	Neural Tube Closure Protein Import Into Nucleus Positive Regulation Of Protein Ubiquitination Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Aorta Development Negative Regulation Of Transcription, DNA-templated Wnt Signaling Pathway, Planar Cell Polarity Pathway Coronary Vasculature Development Negative Regulation Of Canonical Wnt Signaling Pathway Negative Regulation Of Cardiac Muscle Cell Myoblast Differentiation	Neural Fold Formation Neural Tube Closure Apoptotic DNA Fragmentation Cytoskeleton Organization Single Fertilization Vesicle-mediated Transport ATP-dependent Chromatin Remodeling Inner Ear Receptor Cell Stereocilium Organization Cytoskeleton-dependent Cytokinesis Cochlea Development Execution Phase Of Apoptosis
Pathways		Asymmetric localization of PCP proteins
Drugs
Diseases		Progressive myoclonic epilepsy (PME), including: Lafora disease (LBD); Unverricht-Lundborg disease (ULD); Neuronal ceroid lipofuscinoses (NCL); Type I sialidosis; Action myoclonus-renal failure syndrome (AMRF); Type III Gaucher disease (GD)
GWAS		Autoimmune thyroid diseases (Graves disease or Hashimoto's thyroiditis) ( 22922229) Blood urea nitrogen levels ( 31152163) Colorectal cancer ( 30529582 31826910) Endometrial cancer (Non-endometrioid histology) ( 30093612) Graves' disease ( 22922229) Heart failure ( 20445134) Hip circumference adjusted for BMI ( 28552196) Impulsivity (non-planning) ( 30718321) Inferior parietal cortex volume ( 31530798) Multiple sclerosis ( 31604244) Night sleep phenotypes ( 27126917) Parkinson's disease ( 27182965) Refractive error ( 32231278) Visceral adipose tissue/subcutaneous adipose tissue ratio ( 22589738)	Waist-to-hip ratio adjusted for BMI x sex interaction ( 26426971)
Interacting Genes		7 interacting genes: BYSL JRK KIF9 PRPF31 SMURF2 UTP14C VIP	2 interacting genes: LRPPRC UXT
Entrez ID		144165	27443
HPRD ID		16341	10463
Ensembl ID		ENSG00000139174	ENSG00000099954
Uniprot IDs		A0A024R0W7 B3KVG3 B3KVG6 Q96MT3	B7WPH3 Q9BXF3
PDB IDs			3NXB 5V84
Enriched GO Terms of Interacting Partners?
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