PRICKLE1 and ARID2

Data Source:
BioGRID (pull down, x-ray crystallography)

		PRICKLE1	ARID2
Description		prickle planar cell polarity protein 1	AT-rich interaction domain 2
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus Cytosol Nuclear Membrane	Nucleoplasm Plasma Membrane
	Molecular Function	Protein Binding Zinc Ion Binding	DNA Binding Protein Binding Metal Ion Binding
	Biological Process	Neural Tube Closure Protein Import Into Nucleus Positive Regulation Of Protein Ubiquitination Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Aorta Development Negative Regulation Of Transcription, DNA-templated Wnt Signaling Pathway, Planar Cell Polarity Pathway Coronary Vasculature Development Negative Regulation Of Canonical Wnt Signaling Pathway Negative Regulation Of Cardiac Muscle Cell Myoblast Differentiation	Heart Morphogenesis Nucleosome Disassembly Regulation Of Transcription, DNA-templated Negative Regulation Of Cell Population Proliferation Negative Regulation Of Cell Migration Homeostatic Process Embryonic Organ Development Cardiac Muscle Cell Proliferation Coronary Artery Morphogenesis Positive Regulation Of Double-strand Break Repair Via Homologous Recombination
Pathways		Asymmetric localization of PCP proteins	RMTs methylate histone arginines RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known
Drugs
Diseases		Progressive myoclonic epilepsy (PME), including: Lafora disease (LBD); Unverricht-Lundborg disease (ULD); Neuronal ceroid lipofuscinoses (NCL); Type I sialidosis; Action myoclonus-renal failure syndrome (AMRF); Type III Gaucher disease (GD)
GWAS		Autoimmune thyroid diseases (Graves disease or Hashimoto's thyroiditis) ( 22922229) Blood urea nitrogen levels ( 31152163) Colorectal cancer ( 30529582 31826910) Endometrial cancer (Non-endometrioid histology) ( 30093612) Graves' disease ( 22922229) Heart failure ( 20445134) Hip circumference adjusted for BMI ( 28552196) Impulsivity (non-planning) ( 30718321) Inferior parietal cortex volume ( 31530798) Multiple sclerosis ( 31604244) Night sleep phenotypes ( 27126917) Parkinson's disease ( 27182965) Refractive error ( 32231278) Visceral adipose tissue/subcutaneous adipose tissue ratio ( 22589738)	Chronotype ( 30696823) Fish- and plant-related diet ( 32066663) Hematocrit ( 32888494) Hemoglobin ( 32888494) Hippocampal atrophy ( 19668339) Intelligence (MTAG) ( 29326435) Mean corpuscular hemoglobin ( 32888494) Morning person ( 30696823) PR interval ( 32439900) Red blood cell count ( 32888494) Refractive error ( 32231278) Spherical equivalent or myopia (age of diagnosis) ( 29808027) Triglyceride levels ( 32203549) Triglycerides ( 30275531)
Interacting Genes		7 interacting genes: BYSL JRK KIF9 PRPF31 SMURF2 UTP14C VIP	6 interacting genes: CCNA1 NFYC SMARCA4 SMARCE1 SUMO2 TSC22D2
Entrez ID		144165	196528
HPRD ID		16341	16505
Ensembl ID		ENSG00000139174	ENSG00000189079
Uniprot IDs		A0A024R0W7 B3KVG3 B3KVG6 Q96MT3	Q68CP9
PDB IDs
Enriched GO Terms of Interacting Partners?
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