PLEKHA7 and ADAM9

Data Source:
BioGRID (proximity labelling technology)

		PLEKHA7	ADAM9
Description		pleckstrin homology domain containing A7	ADAM metallopeptidase domain 9
Image		No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Centrosome Cytosol Zonula Adherens Cell Junction Pore Complex Extracellular Exosome	Extracellular Space Focal Adhesion Cell Surface Integral Component Of Membrane Intrinsic Component Of External Side Of Plasma Membrane Extracellular Exosome
	Molecular Function	Protein Binding Delta-catenin Binding	Metalloendopeptidase Activity Protein Kinase C Binding Integrin Binding Protein Binding Collagen Binding Metallopeptidase Activity SH3 Domain Binding Laminin Binding Metal Ion Binding
	Biological Process	Cell-cell Adhesion Mediated By Cadherin Zonula Adherens Maintenance Pore Complex Assembly Epithelial Cell-cell Adhesion	Activation Of MAPKK Activity Membrane Protein Ectodomain Proteolysis Cell Adhesion Cell-matrix Adhesion Transforming Growth Factor Beta Receptor Signaling Pathway Integrin-mediated Signaling Pathway Response To Manganese Ion Cell Migration Keratinocyte Differentiation Positive Regulation Of Cell Migration Membrane Protein Intracellular Domain Proteolysis Cell Adhesion Mediated By Integrin Positive Regulation Of Cell Adhesion Mediated By Integrin Cell-cell Adhesion Mediated By Integrin Positive Regulation Of Macrophage Fusion Response To Tumor Necrosis Factor Monocyte Activation Response To Hydrogen Peroxide Positive Regulation Of Protein Secretion Positive Regulation Of Membrane Protein Ectodomain Proteolysis Response To Glucocorticoid Positive Regulation Of Keratinocyte Migration Response To Calcium Ion Cellular Response To Lipopolysaccharide
Pathways			Collagen degradation
Drugs			INCB7839
Diseases			Cone-rod dystrophy and cone dystrophy, including: Cone-rod dystrophy (CORD); Cone dystrophy (COD); Retinal cone dystrophy (RCD)
GWAS		Blood pressure ( 21909110) Blood protein levels ( 30072576 29875488) Body mass index ( 26426971) Coronary artery disease ( 29212778) Diastolic blood pressure ( 19430479 27841878 28739976 27618452) Diastolic blood pressure x alcohol consumption interaction (2df test) ( 29912962) Glaucoma (primary angle closure) ( 22922875 27064256) Intraocular pressure ( 29617998 29785010 31959993 30054594) Macular thickness ( 30535121) Mean arterial pressure ( 27618448) Mean arterial pressure x alcohol consumption interaction (2df test) ( 29912962) Microalbuminuria in type 1 diabetes ( 31537649) Systolic blood pressure ( 19430479 27841878 28739976 27618452 30578418) Systolic blood pressure change trajectories ( 27980656) Systolic blood pressure x alcohol consumption interaction (2df test) ( 29912962)	Basophil count ( 32888494)
Interacting Genes		20 interacting genes: B9D2 CCHCR1 CCNDBP1 FAM228A GRB2 HOMEZ HSF2BP IGFBP6 IGFL2 LZTS1 NEK6 PIBF1 PICK1 PPL RDH12 RHOH STMN3 TRAF4 TSGA10 ZMAT5	9 interacting genes: ITGA3 ITGA6 ITGAV MAD2L2 PRKCD SH3D19 SH3GLB1 SNX9 TNF
Entrez ID		144100	8754
HPRD ID		15142	04091
Ensembl ID		ENSG00000166689	ENSG00000168615
Uniprot IDs		E9PKC0 Q6IQ23	Q13443
PDB IDs			1M1V
Enriched GO Terms of Interacting Partners?
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