SYT9 and CSNK1A1

Data Source:
HPRD (in vitro)

		SYT9	CSNK1A1
Description		synaptotagmin 9	casein kinase 1 alpha 1
Image		No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Integral Component Of Synaptic Vesicle Membrane Clathrin-coated Vesicle Membrane Secretory Granule Membrane Dense Core Granule Exocytic Vesicle Hippocampal Mossy Fiber To CA3 Synapse	Condensed Chromosome Kinetochore Nucleus Cytoplasm Centrosome Cytosol MRNA Cleavage And Polyadenylation Specificity Factor Complex Cilium Membrane Nuclear Speck Beta-catenin Destruction Complex Ciliary Basal Body Keratin Filament
	Molecular Function	SNARE Binding Phosphatidylserine Binding Calcium Ion Binding Protein Binding Calcium-dependent Phospholipid Binding Phosphatidylinositol-4,5-bisphosphate Binding Syntaxin Binding Clathrin Binding Identical Protein Binding	Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Kinase Activity Protein Serine Kinase Activity Protein Threonine Kinase Activity
	Biological Process	Regulation Of Dopamine Secretion Vesicle-mediated Transport Calcium-ion Regulated Exocytosis Regulation Of Calcium Ion-dependent Exocytosis Positive Regulation Of Calcium Ion-dependent Exocytosis Regulation Of Insulin Secretion Membrane Organization Cellular Response To Calcium Ion Calcium-dependent Activation Of Synaptic Vesicle Fusion	Protein Phosphorylation Golgi Organization Cell Cycle Signal Transduction Cell Surface Receptor Signaling Pathway Wnt Signaling Pathway Peptidyl-serine Phosphorylation Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Intermediate Filament Cytoskeleton Organization Cell Division Negative Regulation Of Canonical Wnt Signaling Pathway Regulation Of GTP Binding Beta-catenin Destruction Complex Assembly Beta-catenin Destruction Complex Disassembly
Pathways		Neurexins and neuroligins Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis	Degradation of beta-catenin by the destruction complex Beta-catenin phosphorylation cascade Disassembly of the destruction complex and recruitment of AXIN to the membrane Disassembly of the destruction complex and recruitment of AXIN to the membrane Signaling by GSK3beta mutants S33 mutants of beta-catenin aren't phosphorylated S37 mutants of beta-catenin aren't phosphorylated S45 mutants of beta-catenin aren't phosphorylated T41 mutants of beta-catenin aren't phosphorylated APC truncation mutants have impaired AXIN binding AXIN missense mutants destabilize the destruction complex Truncations of AMER1 destabilize the destruction complex Degradation of GLI2 by the proteasome GLI3 is processed to GLI3R by the proteasome Activation of SMO Activation of SMO
Drugs			Fostamatinib
Diseases
GWAS		3-month functional outcome in ischaemic stroke (modified Rankin score) ( 30796134) Breast cancer and/or colorectal cancer ( 29698419) Cerebrospinal fluid p-tau levels in mild cognitive impairment ( 29274321) Chagas cardiomyopathy in Tripanosoma cruzi seropositivity ( 24324551) Dietary fat liking ( 32516399) Familial lung cancer ( 29924316) Lead levels ( 26025379) Malaria ( 31844061) Phospholipid levels (plasma) ( 22359512) QRS duration in Tripanosoma cruzi seropositivity ( 24324551)	Carotid intima media thickness x smoking interaction ( 32117412) Chronic obstructive pulmonary disease ( 30804561) Esophageal cancer ( 21642993)
Interacting Genes		10 interacting genes: CSNK1A1 DNAJC5 NRXN1 SNAP25 SYNCRIP TMBIM6 TMEM50A TRPV1 TUBB UPK1B	48 interacting genes: ACTB ADAP1 AP3B1 AP3B2 APC AXIN1 BID CDC25A CHRM3 CRBN CREM CTNNB1 EIF2B5 ERF FADD GLI3 GNB2 HMGB1 HMGB2 HNRNPC HSPA4 KPNA2 KPNB1 LGALS3 MAPT MDM4 NFATC3 OCLN PDE4D PHLPP1 PPP1CC PPP1R14A PPP2R5A PSEN2 PTEN RCC1 SLC18A2 SNCA SQSTM1 SYT9 TGFBR1 TIAM1 TNFRSF1B TP53 UVRAG YWHAQ YWHAZ ZRANB1
Entrez ID		143425	1452
HPRD ID		11618	02739
Ensembl ID		ENSG00000170743	ENSG00000113712
Uniprot IDs		Q86SS6	B4DER9 P48729 Q6PJ06
PDB IDs			5FQD 6GZD
Enriched GO Terms of Interacting Partners?
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