CR1 and FUT4

Data Source:
HPRD (in vivo)

		CR1	FUT4
Description		complement C3b/C4b receptor 1 (Knops blood group)	fucosyltransferase 4
Image			No pdb structure
GO Annotations	Cellular Component	Cytoskeleton Plasma Membrane Integral Component Of Plasma Membrane Cell Surface Secretory Granule Membrane Plasma Membrane Raft Extracellular Exosome Ficolin-1-rich Granule Membrane	Golgi Apparatus Trans-Golgi Network Cell Surface Membrane Integral Component Of Membrane Golgi Cisterna Membrane Cell Periphery
	Molecular Function	Virus Receptor Activity Complement Component C3b Binding Complement Component C4b Binding Complement Component C4b Receptor Activity Complement Component C3b Receptor Activity Protein Binding	Fucosyltransferase Activity 4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase Activity Alpha-(1->3)-fucosyltransferase Activity
	Biological Process	Positive Regulation Of Activation Of Membrane Attack Complex Negative Regulation Of Activation Of Membrane Attack Complex Complement Receptor Mediated Signaling Pathway Immune Complex Clearance By Erythrocytes Negative Regulation Of Immunoglobulin Production Complement Activation, Alternative Pathway Complement Activation, Classical Pathway Plasma Membrane Organization Positive Regulation Of Cell Population Proliferation Regulation Of Complement Activation Negative Regulation Of Interferon-gamma Production Negative Regulation Of Interleukin-2 Production Negative Regulation Of T Cell Proliferation Neutrophil Degranulation Regulation Of Regulatory T Cell Differentiation Positive Regulation Of Regulatory T Cell Differentiation Negative Regulation Of Complement Activation Negative Regulation Of Cytolysis Negative Regulation Of Complement Activation, Alternative Pathway Negative Regulation Of Complement Activation, Classical Pathway Viral Entry Into Host Cell Negative Regulation Of Serine-type Endopeptidase Activity Positive Regulation Of Serine-type Endopeptidase Activity Negative Regulation Of Plasma Cell Differentiation ATP Export	Carbohydrate Metabolic Process Protein Glycosylation Oligosaccharide Metabolic Process Fucosylation L-fucose Catabolic Process Regulation Of Leukocyte Cell-cell Adhesion Positive Regulation Of Leukocyte Tethering Or Rolling
Pathways		Neutrophil degranulation RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs) Regulation of Complement cascade	Lewis blood group biosynthesis
Drugs
Diseases
GWAS		Alzheimer's disease ( 21460840 19734903 31473137) Alzheimer's disease (late onset) ( 21460841 30617256 24162737 28714976) Alzheimer's disease (onset between ages 58 and 79) ( 30979435) Alzheimer's disease in APOE e4+ carriers ( 25778476) Alzheimer's disease or family history of Alzheimer's disease ( 30617256) Alzheimer's disease or fasting insulin levels (pleiotropy) ( 30805717) Erythrocyte sedimentation rate ( 21700265) Family history of Alzheimer's disease ( 30617256) Inflammatory biomarkers ( 22291609) Metabolite levels ( 23823483) Refractive error ( 32231278) Systemic sclerosis ( 29293537)	Metabolite levels ( 23823483) Response to angiotensin II receptor blocker therapy ( 22566498) Response to angiotensin II receptor blocker therapy (opposite direction w/ diuretic therapy) ( 22566498) Small cell lung carcinoma ( 28604730)
Interacting Genes		6 interacting genes: C1QA C3 C4A CD55 CR2 FUT4	3 interacting genes: CR1 ITGB2 SELP
Entrez ID		1378	2526
HPRD ID		00398	00083
Ensembl ID		ENSG00000203710	ENSG00000196371
Uniprot IDs		E9PDY4 P17927	P22083
PDB IDs		1GKG 1GKN 1GOP 1PPQ 2MCY 2MCZ 2Q7Z 5FO9
Enriched GO Terms of Interacting Partners?
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