SSMEM1 and ALG3

Data Source:
BioGRID (two hybrid)

		SSMEM1	ALG3
Description		serine rich single-pass membrane protein 1	ALG3 alpha-1,3- mannosyltransferase
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Integral Component Of Membrane	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Integral Component Of Membrane
	Molecular Function	Protein Binding	Alpha-1,3-mannosyltransferase Activity Protein Binding Dol-P-Man:Man(5)GlcNAc(2)-PP-Dol Alpha-1,3-mannosyltransferase Activity
	Biological Process		Protein Glycosylation Dolichol-linked Oligosaccharide Biosynthetic Process Mannosylation
Pathways			Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein Defective ALG3 causes ALG3-CDG (CDG-1d)
Drugs
Diseases			Congenital disorders of glycosylation (CDG) type I
GWAS		Neurological blood protein biomarker levels ( 31320639)	Major depressive disorder ( 22472876)
Interacting Genes		95 interacting genes: ALG3 APOA2 AQP1 AQP10 AQP3 ATP6V0C BET1 BLCAP C11orf24 C1QL4 C4orf3 C5 CCL4L2 CDS2 CLRN2 CMTM7 CSGALNACT2 CTSA CXCL16 CXCL9 CYB561 CYBC1 DEFB103A DEFB103B DEFB121 EFNA5 EMD ERG28 ERMP1 FAM3C FATE1 FDPS FPR2 GJB2 GPHB5 GPR151 HMOX2 LAT LEPROTL1 LNPEP MARCHF2 MCRS1 MFSD12 MFSD5 MFSD6 MIP MMD2 MS4A13 NIPAL4 NRM PGAP2 PLPP1 PLPP4 PLPP6 PLPPR2 RHD RTP2 RUSF1 S1PR5 SERP1 SLC35A1 SLC35C2 SLC35E3 SLC38A1 SLC38A7 SLC39A2 SLC39A9 SLC41A1 SLC41A2 STX8 TAP1 TAS2R10 TLCD1 TM6SF2 TMEM128 TMEM14A TMEM14C TMEM203 TMEM218 TMEM222 TMEM239 TMEM243 TMEM45A TMEM60 TMEM86A TMEM86B TMEM97 TMPPE TNF TRARG1 UNC93B1 UPK1B VAMP4 YIPF6 ZFPL1	7 interacting genes: ARL13B CD79A CREB3 LMNA SERP1 SSMEM1 TMEM52B
Entrez ID		136263	10195
HPRD ID		14060	03067
Ensembl ID		ENSG00000165120	ENSG00000214160
Uniprot IDs		A0A3B3ISA2 A4D1L0 Q8WWF3	C9J7S5 Q92685
PDB IDs
Enriched GO Terms of Interacting Partners?
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