CPB2 and DPYD

Data Source:
BioGRID (affinity chromatography technology)

		CPB2	DPYD
Description		carboxypeptidase B2	dihydropyrimidine dehydrogenase
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Extracellular Exosome	Cytoplasm Cytosol
	Molecular Function	Metallocarboxypeptidase Activity Zinc Ion Binding	Uracil Binding Protein Binding Dihydropyrimidine Dehydrogenase (NADP+) Activity Protein Homodimerization Activity Metal Ion Binding Flavin Adenine Dinucleotide Binding NADP Binding Iron-sulfur Cluster Binding 4 Iron, 4 Sulfur Cluster Binding
	Biological Process	Positive Regulation Of Extracellular Matrix Constituent Secretion Proteolysis Blood Coagulation Response To Heat Negative Regulation Of Plasminogen Activation Regulation Of Complement Activation Response To Drug Fibrinolysis Negative Regulation Of Fibrinolysis Cellular Response To Glucose Stimulus Liver Regeneration Negative Regulation Of Hepatocyte Proliferation	Purine Nucleobase Catabolic Process Pyrimidine Nucleobase Catabolic Process Thymine Catabolic Process Uracil Catabolic Process Thymidine Catabolic Process Beta-alanine Biosynthetic Process UMP Catabolic Process DUMP Catabolic Process Pyrimidine Nucleoside Catabolic Process
Pathways		Metabolism of Angiotensinogen to Angiotensins Regulation of Complement cascade	Pyrimidine catabolism
Drugs		AZD-9684 Prothrombin	(5S)-5-Iododihydro-2,4(1H,3H)-pyrimidinedione NADPH 6-Carboxymethyluracil Flavin adenine dinucleotide Flavin mononucleotide Uracil Eniluracil 5-Iodouracil Gimeracil Tegafur-uracil
Diseases			Dihydropyrimidine dehydrogenase deficiency
GWAS		Blood protein levels ( 29875488 28240269) Thrombin-activatable fibrinolysis inhibitor activation peptide ( 29378355) Thrombin-activatable fibrinolysis inhibitor levels ( 29378355)	Adult body size ( 32376654) Adverse response to drug ( 30420678) Anthropometric traits (multi-trait analysis) ( 30166351) Anxiety/tension (special factor of neuroticism) ( 30867560) Autism spectrum disorder or schizophrenia ( 28540026) Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined) ( 23453885) Body mass index ( 25673413 29273807) Borderline personality disorder ( 28632202) Chronotype ( 30696823) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) Coronary artery disease ( 29212778) Extremely high intelligence ( 29520040) Face memory ( 31596458) Feeling nervous ( 29500382) Gastroesophageal reflux disease ( 31527586) Gut microbiota (bacterial taxa, rank normal transformation method) ( 32572223) Heel bone mineral density ( 30598549) Household income (MTAG) ( 31844048) Intelligence (MTAG) ( 29326435) Irritable mood ( 29500382) Menarche (age at onset) ( 25231870) Metabolite levels ( 23823483) Methadone dose in opioid dependence ( 28115739) Platelet count ( 21507922) Regular attendance at a pub or social club ( 29970889) Schizophrenia ( 25056061 29483656 22688191 30285260 23974872) Sleep duration ( 30531941) Sleep duration (short sleep) ( 30846698) Triglyceride levels ( 32203549 32154731) Waist-to-hip ratio adjusted for BMI ( 28552196)
Interacting Genes		6 interacting genes: A2M C5 F2 PLG PZP TINAG	3 interacting genes: CLK1 GOPC LXN
Entrez ID		1361	1806
HPRD ID		04374	02036
Ensembl ID		ENSG00000080618	ENSG00000188641
Uniprot IDs		A0A087WSY5 Q96IY4	Q12882
PDB IDs		3D66 3D67 3D68 3LMS 4P10 5HVF 5HVG 5HVH
Enriched GO Terms of Interacting Partners?
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