CMBL and FBN2

Data Source:
BioGRID (biochemical)

		CMBL	FBN2
Description		carboxymethylenebutenolidase homolog	fibrillin 2
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cytosol Extracellular Exosome	Microfibril Extracellular Region Extracellular Matrix Collagen-containing Extracellular Matrix
	Molecular Function	Hydrolase Activity	Extracellular Matrix Structural Constituent Calcium Ion Binding Protein Binding Extracellular Matrix Constituent Conferring Elasticity
	Biological Process	Xenobiotic Metabolic Process	Anatomical Structure Morphogenesis Extracellular Matrix Organization Embryonic Limb Morphogenesis Positive Regulation Of Bone Mineralization Sequestering Of TGFbeta In Extracellular Matrix Camera-type Eye Development Positive Regulation Of Osteoblast Differentiation Embryonic Eye Morphogenesis Bone Trabecula Formation
Pathways		Phase I - Functionalization of compounds	Degradation of the extracellular matrix Elastic fibre formation Molecules associated with elastic fibres Molecules associated with elastic fibres
Drugs			Calcium citrate Calcium Phosphate Calcium phosphate dihydrate
Diseases			Congenital contractural arachnodactyly (CCA) ; Beals syndrome
GWAS		Metabolite levels ( 23823483)	Atrial fibrillation ( 29892015) Beard thickness ( 26926045) Brain morphology (MOSTest) ( 32665545) Breastfeeding duration ( 25475840) Central corneal thickness ( 32528159) Cortical surface area (MOSTest) ( 32665545) Diastolic blood pressure ( 27841878) Heel bone mineral density ( 30598549) Height ( 21998595 31562340) Heschl's gyrus morphology ( 25130324) Intraocular pressure ( 29617998) Medication use (beta blocking agents) ( 31015401) Medication use (calcium channel blockers) ( 31015401) Medication use (diuretics) ( 31015401) Multiple system atrophy ( 27629089) Night sleep phenotypes ( 27126917) Obesity (extreme) ( 19553259) Pulse pressure ( 27841878 30578418) Refractive error ( 32231278) Response to fenofibrate (total cholesterol levels) ( 27002377) Severe aplastic anemia ( 32004448) Subcortical volume (MOSTest) ( 32665545) Systolic blood pressure ( 28135244 27841878 30578418) Temperament ( 22832960)
Interacting Genes			7 interacting genes: ELN FBN1 LTBP1 MATN2 MFAP2 MFAP5 SMAD2
Entrez ID		134147	2201
HPRD ID		14055	00416
Ensembl ID		ENSG00000164237	ENSG00000138829
Uniprot IDs		Q96DG6	P35556
PDB IDs
Enriched GO Terms of Interacting Partners?
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