ADORA1 and EPB41L2

Data Source:
HPRD (two hybrid, in vivo, in vitro)

		ADORA1	EPB41L2
Description		adenosine A1 receptor	erythrocyte membrane protein band 4.1 like 2
Image			No pdb structure
GO Annotations	Cellular Component	Endoplasmic Reticulum Plasma Membrane Integral Component Of Plasma Membrane Postsynaptic Density Basolateral Plasma Membrane Axolemma Neuronal Cell Body Terminal Bouton Dendritic Spine Calyx Of Held Presynaptic Active Zone Integral Component Of Postsynaptic Membrane Integral Component Of Presynaptic Membrane	Nucleoplasm Cytosol Cytoskeleton Plasma Membrane Focal Adhesion Spectrin COP9 Signalosome Cell Junction Extracellular Exosome Cell Cortex Region
	Molecular Function	G Protein-coupled Adenosine Receptor Activity G Protein-coupled Receptor Binding Purine Nucleoside Binding Protein Binding Heat Shock Protein Binding G-protein Beta/gamma-subunit Complex Binding Heterotrimeric G-protein Binding Protein Heterodimerization Activity Neurotransmitter Receptor Activity Involved In Regulation Of Presynaptic Cytosolic Calcium Ion Concentration	Actin Binding Structural Molecule Activity Protein Binding Spectrin Binding PH Domain Binding
	Biological Process	Activation Of MAPKK Activity Temperature Homeostasis Response To Hypoxia G Protein-coupled Adenosine Receptor Signaling Pathway Regulation Of Respiratory Gaseous Exchange By Nervous System Process Negative Regulation Of Acute Inflammatory Response Negative Regulation Of Leukocyte Migration Positive Regulation Of Peptide Secretion Positive Regulation Of Systemic Arterial Blood Pressure Negative Regulation Of Systemic Arterial Blood Pressure Regulation Of Glomerular Filtration Protein Targeting To Membrane Phagocytosis Inflammatory Response Signal Transduction G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Cell-cell Signaling Nervous System Development Negative Regulation Of Cell Population Proliferation Negative Regulation Of Glutamate Secretion Lipid Catabolic Process Negative Regulation Of Synaptic Transmission, GABAergic Positive Regulation Of Nucleoside Transport Negative Regulation Of Neurotrophin Production Positive Regulation Of Protein Dephosphorylation Negative Regulation Of Renal Sodium Excretion Negative Regulation Of Circadian Sleep/wake Cycle, Non-REM Sleep Negative Regulation Of Apoptotic Process Positive Regulation Of Potassium Ion Transport Positive Regulation Of Epidermal Growth Factor-activated Receptor Activity Negative Regulation Of Heart Contraction Negative Regulation Of Hormone Secretion Cognition Detection Of Temperature Stimulus Involved In Sensory Perception Of Pain Negative Regulation Of Lipid Catabolic Process Positive Regulation Of Lipid Catabolic Process Regulation Of Sensory Perception Of Pain Negative Regulation Of Synaptic Transmission, Glutamatergic Fatty Acid Homeostasis Excitatory Postsynaptic Potential Relaxation Of Vascular Associated Smooth Muscle Negative Regulation Of Mucus Secretion Triglyceride Homeostasis Regulation Of Cardiac Muscle Cell Contraction Apoptotic Signaling Pathway Regulation Of Presynaptic Cytosolic Calcium Ion Concentration Negative Regulation Of Long-term Synaptic Potentiation Negative Regulation Of Long-term Synaptic Depression Positive Regulation Of Neuron Death	Cell Cycle Cortical Actin Cytoskeleton Organization Actomyosin Structure Organization Cell Division Positive Regulation Of Protein Localization To Cell Cortex
Pathways		Adenosine P1 receptors G alpha (i) signalling events	Neurexins and neuroligins
Drugs		Tramadol Caffeine Theophylline Lamotrigine Adenosine Dyphylline Pentoxifylline Enprofylline Gabapentin Aminophylline Oxtriphylline Theobromine Defibrotide Tecadenoson Naxifylline Cannabidiol Istradefylline Tonapofylline Rolofylline
Diseases
GWAS		Asthma ( 31361310 31959851 30929738 27182965 32296059 31619474) Asthma (childhood onset) ( 31036433 30929738) Clozapine-induced agranulocytosis ( 25187353) Systolic blood pressure ( 30224653)	Cerebellum white matter volume ( 31530798) Colorectal cancer (calcium intake interaction) ( 25192705) Creativity ( 32133506) Heel bone mineral density ( 30598549 28869591) Height ( 31562340) Lentiform nucleus volume ( 22903471) Loneliness ( 31518406 29970889) Loneliness (MTAG) ( 29970889) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 27863252) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Pars triangularis volume ( 31530798) Plateletcrit ( 32888494) Response to statins (LDL cholesterol change) ( 22331829) Systolic blood pressure ( 30224653) Urolithiasis ( 30975718)
Interacting Genes		12 interacting genes: ADA ATXN1L DRD1 EPB41L2 GNAI2 GNAO1 GNAS GNAZ GRM1 P2RY1 SNF8 TSHR	15 interacting genes: ACTA1 ADORA1 APP ATXN1L DRD1 DRD3 FKBP2 GRIA1 GRM1 HSPB1 NUMA1 SPTAN1 YWHAG YWHAH YWHAZ
Entrez ID		134	2037
HPRD ID		00042	09126
Ensembl ID		ENSG00000163485	ENSG00000079819
Uniprot IDs		B7Z1L9 P30542	B4DJ76 I6L9B1 O43491 Q59FD8
PDB IDs		5N2S 5UEN 6D9H
Enriched GO Terms of Interacting Partners?
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