SCLT1 and SCN10A

Data Source:
HPRD (two hybrid, in vitro, in vivo)

		SCLT1	SCN10A
Description		sodium channel and clathrin linker 1	sodium voltage-gated channel alpha subunit 10
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Centrosome Centriole Cytosol Clathrin Complex Ciliary Transition Fiber	Voltage-gated Sodium Channel Complex Axon Extracellular Exosome
	Molecular Function	Protein C-terminus Binding Sodium Channel Regulator Activity Clathrin Binding	Voltage-gated Ion Channel Activity Voltage-gated Sodium Channel Activity Ion Channel Binding
	Biological Process	Clustering Of Voltage-gated Sodium Channels Cilium Assembly Ciliary Basal Body-plasma Membrane Docking	Regulation Of Heart Rate Sensory Perception Neuronal Action Potential Sensory Perception Of Pain Regulation Of Ion Transmembrane Transport Sodium Ion Transmembrane Transport Regulation Of Cardiac Muscle Contraction Regulation Of Atrial Cardiac Muscle Cell Membrane Depolarization Membrane Depolarization During Action Potential AV Node Cell Action Potential Bundle Of His Cell Action Potential
Pathways		Anchoring of the basal body to the plasma membrane	Interaction between L1 and Ankyrins Phase 0 - rapid depolarisation
Drugs			Ranolazine Topiramate Lidocaine Ropivacaine Bupivacaine Valproic acid Hexylcaine Cinchocaine Lamotrigine Carbamazepine Dyclonine Procaine Oxcarbazepine Proparacaine Oxybuprocaine Cocaine Mepivacaine Levobupivacaine Promethazine Benzocaine Chloroprocaine Orphenadrine Brivaracetam Lacosamide Tetracaine Amylocaine Propoxycaine Pramocaine Pentoxyverine Dichlorobenzyl alcohol Bioallethrin Fish oil
Diseases
GWAS		Chronic obstructive pulmonary disease (moderate to severe) ( 24621683) Metabolite levels ( 23823483) Problematic alcohol use in trauma-exposed individuals ( 29082582) Triglyceride levels x loop diuretics use interaction ( 31806883)	Atrial fibrillation ( 30061737 29892015) Atrioventricular conduction ( 21041692) Brugada syndrome ( 23872634 32619740) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Electrocardiographic conduction measures ( 23463857) Electrocardiographic traits ( 32602732 20062061 20062063 25055868) Heart rate response to exercise ( 29769521) Heart rate response to recovery post exercise ( 29769521) P wave duration ( 28794112 24850809) PR interval ( 30679814 29127183 30046033 32439900 20062060 25035420 23139255 21347284) PR segment ( 24850809) Pulse pressure ( 30224653 30578418) QRS duration ( 30679814 27577874 31251759 30012220 25035420 21076409 27659466) QT interval ( 24952745 29874175) Systemic lupus erythematosus ( 23273568) T wave morphology restitution during exercise ( 31607149) T wave morphology restitution during exercise (MTAG) ( 31607149) T wave morphology restitution during recovery from exercise ( 31607149) T wave morphology restitution during recovery from exercise (MTAG) ( 31607149)
Interacting Genes		5 interacting genes: CALM1 IKBKG LNX1 MAPK8IP2 SCN10A	2 interacting genes: ACTB SCLT1
Entrez ID		132320	6336
HPRD ID		08700	09188
Ensembl ID		ENSG00000151466	ENSG00000185313
Uniprot IDs		D6RBA6 Q96NL6	Q9Y5Y9
PDB IDs
Enriched GO Terms of Interacting Partners?
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