ADK and SRD5A3

Data Source:
BioGRID (two hybrid)

		ADK	SRD5A3
Description		adenosine kinase	steroid 5 alpha-reductase 3
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytosol Plasma Membrane	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Integral Component Of Membrane
	Molecular Function	RNA Binding Adenosine Kinase Activity ATP Binding Metal Ion Binding	3-oxo-5-alpha-steroid 4-dehydrogenase Activity Oxidoreductase Activity, Acting On The CH-CH Group Of Donors, NAD Or NADP As Acceptor Cholestenone 5-alpha-reductase Activity Polyprenol Reductase Activity
	Biological Process	Purine Ribonucleoside Salvage DATP Biosynthetic Process Ribonucleoside Monophosphate Biosynthetic Process Phosphorylation Purine-containing Compound Salvage AMP Salvage	Dolichol-linked Oligosaccharide Biosynthetic Process Dolichyl Diphosphate Biosynthetic Process Androgen Biosynthetic Process Polyprenol Catabolic Process Dolichol Metabolic Process Dolichol Biosynthetic Process
Pathways		Purine salvage	Androgen biosynthesis Synthesis of Dolichyl-phosphate Defective SRD5A3 causes SRD5A3-CDG (CDG-1q) and KHRZ
Drugs		Adenosine phosphate 7-(5-DEOXY-BETA-D-RIBOFURANOSYL)-5-IODO-7H-PYRROLO[2,3-D]PYRIMIDIN-4-AMINE 5-[4-(DIMETHYLAMINO)PHENYL]-6-[(6-MORPHOLIN-4-YLPYRIDIN-3-YL)ETHYNYL]PYRIMIDIN-4-AMINE	Spironolactone
Diseases
GWAS		Adult body size ( 32376654) Cardiac troponin-I levels ( 31014085) Diverticular disease ( 30177863) Drug experimentation measurement ( 30718321) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223) Hypospadias ( 25108383) Lymphocyte counts ( 32888494) Monocyte count ( 32888494) Permanent tooth development ( 21931568) Platelet count ( 32888494) Plateletcrit ( 32888494) Primary tooth development (number of teeth) ( 23704328) Primary tooth development (time to first tooth eruption) ( 23704328) Refractive error ( 32231278) Soluble interleukin-2 receptor subunit alpha ( 26293465) Systolic blood pressure ( 30578418)	Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (MOSTest) ( 32665545) PR interval ( 32439900) Subcortical volume (MOSTest) ( 32665545) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)
Interacting Genes		2 interacting genes: FICD SRD5A3	2 interacting genes: ADK NUDT15
Entrez ID		132	79644
HPRD ID		00039	07825
Ensembl ID		ENSG00000156110	ENSG00000128039
Uniprot IDs		A0A140VJE0 A0A5F9ZH72 A0A5F9ZHJ1 P55263	Q9H8P0
PDB IDs		1BX4 2I6A 2I6B 4O1L
Enriched GO Terms of Interacting Partners?
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