COL6A1 and CFAP410

Data Source:
BioGRID (biochemical)

		COL6A1	CFAP410
Description		collagen type VI alpha 1 chain	cilia and flagella associated protein 410
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Extracellular Region Collagen Type VI Trimer Extracellular Space Lysosomal Membrane Endoplasmic Reticulum Lumen Membrane Protein-containing Complex Sarcolemma Collagen-containing Extracellular Matrix Extracellular Exosome	Photoreceptor Outer Segment Cytoplasm Mitochondrion Cytosol Plasma Membrane Photoreceptor Connecting Cilium Ciliary Basal Body Intracellular Membrane-bounded Organelle
	Molecular Function	Collagen Binding Extracellular Matrix Structural Constituent Conferring Tensile Strength Platelet-derived Growth Factor Binding	Molecular_function Protein Binding
	Biological Process	Osteoblast Differentiation Cell Adhesion Extracellular Matrix Organization Endodermal Cell Differentiation Cellular Response To Amino Acid Stimulus	Cytoskeleton Organization Regulation Of Cell Shape DNA Damage Response, Detection Of DNA Damage Cilium Assembly
Pathways		Collagen degradation Collagen biosynthesis and modifying enzymes Signaling by PDGF Assembly of collagen fibrils and other multimeric structures Integrin cell surface interactions ECM proteoglycans ECM proteoglycans NCAM1 interactions Collagen chain trimerization
Drugs
Diseases		Ossification of the posterior longitudinal ligament of spine (OPLL) Congenital muscular dystrophies (CMD/MDC), including: Merosin-deficient CMD (MDC1A); Ullrich CMD (UCMD); Integrin alpha7-deficient CMD; CMD with joint hyperlaxity (CMDH); CMD with epidermolysis bullosa; Walker-Warburg syndrome (WWS); Muscle-eye-brain disease (MEB); Fukuyama CMD (FCMD); CMD with muscle hypertrophy (MDC1C); CMD with severe intellectual impairment and abnormal glycosylation (MDC1D); Rigid spine syndrome (RSS); LMNA-deficient CMD; CMD with respiratory failure and muscle hypertrophy (MDC1B); Bethlem myopathy
GWAS		Blood protein levels ( 30072576 29875488) Bone mineral density (lumbar spine) in inflammatory bowel disease ( 29603369) Corneal hysteresis ( 30894546) Corneal resistance factor ( 31246245 30894546) Diverticular disease ( 30177863) Intraocular pressure ( 29617998 29235454) Myopia ( 27182965) Pulse pressure ( 30224653 30578418) Refractive error ( 32231278) Spherical equivalent or myopia (age of diagnosis) ( 29808027) Systolic blood pressure ( 28234671) Waist circumference adjusted for body mass index ( 25673412)
Interacting Genes		10 interacting genes: COL2A1 DCN DNAJB11 FGF7 LAMB1 LGALS3BP MAG MTDH PDGFA PDGFB	3 interacting genes: ATOX1 GMCL1 SPG21
Entrez ID		1291	755
HPRD ID		00370	04427
Ensembl ID		ENSG00000142156	ENSG00000160226
Uniprot IDs		A0A384P5H7 P12109	O43822
PDB IDs
Enriched GO Terms of Interacting Partners?
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