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PIGU and F2RL1
Data Source:
BioGRID
(two hybrid)
PIGU
F2RL1
Description
phosphatidylinositol glycan anchor biosynthesis class U
F2R like trypsin receptor 1
Image
No pdb structure
GO Annotations
Cellular Component
Endoplasmic Reticulum Membrane
Plasma Membrane
Membrane
GPI-anchor Transamidase Complex
Early Endosome
Golgi Apparatus
Plasma Membrane
Integral Component Of Plasma Membrane
Pseudopodium
Molecular Function
Protein Binding
GPI Anchor Binding
G-protein Alpha-subunit Binding
G Protein-coupled Receptor Activity
Signaling Receptor Binding
Protein Binding
Thrombin-activated Receptor Activity
G-protein Beta-subunit Binding
Signaling Receptor Activity
Biological Process
GPI Anchor Biosynthetic Process
Attachment Of GPI Anchor To Protein
Protein Localization To Cell Surface
Regulation Of Receptor Signaling Pathway Via JAK-STAT
T Cell Activation Involved In Immune Response
Positive Regulation Of Leukocyte Chemotaxis
Positive Regulation Of Cytokine Production Involved In Immune Response
Positive Regulation Of Glomerular Filtration
Inflammatory Response
G Protein-coupled Receptor Signaling Pathway
Positive Regulation Of Cytosolic Calcium Ion Concentration
Blood Coagulation
Negative Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway
Positive Regulation Of Phosphatidylinositol 3-kinase Signaling
Regulation Of Blood Coagulation
Positive Regulation Of Cell Migration
Positive Regulation Of Actin Filament Depolymerization
Positive Regulation Of Pseudopodium Assembly
Chemokine Production
Interferon-gamma Production
Interleukin-1 Beta Production
Interleukin-10 Production
Negative Regulation Of Chemokine Production
Positive Regulation Of Interleukin-6 Production
Positive Regulation Of Interleukin-8 Production
Positive Regulation Of Superoxide Anion Generation
Positive Regulation Of Toll-like Receptor 2 Signaling Pathway
Negative Regulation Of Toll-like Receptor 3 Signaling Pathway
Positive Regulation Of Toll-like Receptor 3 Signaling Pathway
Positive Regulation Of Toll-like Receptor 4 Signaling Pathway
Positive Regulation Of Rho Protein Signal Transduction
Neutrophil Activation
Vasodilation
Regulation Of I-kappaB Kinase/NF-kappaB Signaling
Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling
Positive Regulation Of Eosinophil Degranulation
Positive Regulation Of GTPase Activity
Innate Immune Response
Cell-cell Junction Maintenance
Positive Regulation Of Transcription By RNA Polymerase II
Regulation Of JNK Cascade
Negative Regulation Of JNK Cascade
Positive Regulation Of JNK Cascade
Leukocyte Migration
Positive Regulation Of Chemotaxis
Positive Regulation Of Positive Chemotaxis
Positive Regulation Of Cytosolic Calcium Ion Concentration Involved In Phospholipase C-activating G Protein-coupled Signaling Pathway
Defense Response To Virus
Positive Regulation Of Phagocytosis, Engulfment
Establishment Of Endothelial Barrier
Positive Regulation Of ERK1 And ERK2 Cascade
Thrombin-activated Receptor Signaling Pathway
Leukocyte Proliferation
Positive Regulation Of Neutrophil Mediated Killing Of Gram-negative Bacterium
Mature Conventional Dendritic Cell Differentiation
Positive Regulation Of Renin Secretion Into Blood Stream
Regulation Of Chemokine (C-X-C Motif) Ligand 2 Production
Pathways
Attachment of GPI anchor to uPAR
Peptide ligand-binding receptors
G alpha (q) signalling events
Drugs
Diseases
GWAS
Bipolar disorder (
31043756
)
Brown vs. black hair color (
30531825
)
Colorectal cancer or advanced adenoma (
30510241
)
Cutaneous melanoma or hair colour (
32341527
)
Estimated glomerular filtration rate (
31152163
)
Fish- and plant-related diet (
32066663
)
Lipid traits (pleiotropy) (HIPO component 1) (
30289880
)
Melanoma (
28212542
)
Oily fish consumption (
32066663
)
Pork consumption (
32066663
)
Smoking status (ever vs never smokers) (
30643258
)
Waist-to-hip ratio adjusted for BMI (
26426971
)
Waist-to-hip ratio adjusted for BMI (age >50) (
26426971
)
Waist-to-hip ratio adjusted for BMI x sex interaction (
26426971
)
Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) (
26426971
)
Weight (
28552196
)
Serum bilirubin levels x sex interaction in metabolic syndrome (
30621171
)
Interacting Genes
3 interacting genes:
F2RL1
GPAA1
KASH5
76 interacting genes:
ABCC8
ABHD14A
ADCY2
ARL6IP1
ATP2A2
ATP2B1
ATP2C1
BSG
CANX
CAPN1
CAPN2
CAPNS1
CBL
CD63
CD81
CLPTM1
CNN3
COPS5
CRLS1
CTNNA1
CTSG
DNMT3L
ELANE
ERGIC3
F2
GJB6
GJC2
GPRASP1
HERPUD1
HLA-E
HMOX2
HSPA1B
ICAM2
KDELR1
KLC1
LMNA
MFSD10
MORN4
NAT14
NBPF15
OSTC
P4HTM
PHLDA1
PIGU
PLG
PPM1J
PRNP
PRRT2
PRTN3
PSMC3
PTDSS2
QSER1
R3HDM1
RGR
RTN1
RTN4
SCN1B
SDHD
SLC12A5
SLC18B1
SLC1A4
SLC31A2
SLC32A1
SLC35A1
SLC39A13
SLC43A2
ST14
SYNGR2
TMBIM1
TMED1
TMEM161A
TMEM62
TMX2
WFS1
YIPF1
YIPF6
Entrez ID
128869
2150
HPRD ID
12250
02960
Ensembl ID
ENSG00000101464
ENSG00000164251
Uniprot IDs
Q9H490
P55085
PDB IDs
5NDD
5NDZ
5NJ6
Enriched GO Terms of Interacting Partners
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Tagcloud (Intersection)
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