DUSP15 and POFUT1

Data Source:
HPRD (in vitro, in vivo)

		DUSP15	POFUT1
Description		dual specificity phosphatase 15	protein O-fucosyltransferase 1
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GO Annotations	Cellular Component	Cytosol Plasma Membrane	Endoplasmic Reticulum Membrane
	Molecular Function	Protein Tyrosine Phosphatase Activity Protein Binding Protein Tyrosine/serine/threonine Phosphatase Activity Phosphatase Activity Protein Serine Phosphatase Activity Protein Threonine Phosphatase Activity	Fucosyltransferase Activity Peptide-O-fucosyltransferase Activity
	Biological Process	Transforming Growth Factor Beta Receptor Signaling Pathway Dephosphorylation Peptidyl-tyrosine Dephosphorylation Regulation Of Cell Population Proliferation Positive Regulation Of JNK Cascade	Angiogenesis Somitogenesis Fucose Metabolic Process Regulation Of Transcription, DNA-templated Protein O-linked Glycosylation Notch Signaling Pathway Nervous System Development Heart Development Regulation Of Notch Signaling Pathway O-glycan Processing Protein O-linked Fucosylation
Pathways			Pre-NOTCH Processing in the Endoplasmic Reticulum
Drugs
Diseases
GWAS		Brain morphology (MOSTest) ( 32665545)	Blood protein levels ( 30072576 29875488) Chronic obstructive pulmonary disease ( 28166215) Chronic obstructive pulmonary disease or high blood pressure (pleiotropy) ( 30940143) Inflammatory bowel disease ( 28067908)
Interacting Genes		2 interacting genes: IGF1R PTK7	4 interacting genes: AKT2 DLL1 JAG1 NOTCH1
Entrez ID		128853	23509
HPRD ID		13252	06319
Ensembl ID		ENSG00000149599	ENSG00000101346
Uniprot IDs		Q9H1R2	Q9H488
PDB IDs		1YZ4	5UX6 5UXH
Enriched GO Terms of Interacting Partners?
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