WFIKKN2 and MSTN

Data Source:
HPRD (in vitro)

		WFIKKN2	MSTN
Description		WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 2	myostatin
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Space	Extracellular Space Cytoplasm
	Molecular Function	Serine-type Endopeptidase Inhibitor Activity Protein Binding Metalloendopeptidase Inhibitor Activity Receptor Antagonist Activity Transforming Growth Factor Beta Binding	Signaling Receptor Binding Cytokine Activity Protein Binding Growth Factor Activity Heparin Binding Identical Protein Binding Protein Homodimerization Activity
	Biological Process	Skeletal System Development Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Endopeptidase Activity Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Protein Binding Negative Regulation Of DNA Binding Muscle Fiber Development Roof Of Mouth Development Negative Regulation Of Signaling Receptor Activity	Transforming Growth Factor Beta Receptor Signaling Pathway Muscle Organ Development Response To Heat Response To Gravity Positive Regulation Of Lamellipodium Assembly Positive Regulation Of Macrophage Chemotaxis Positive Regulation Of Pathway-restricted SMAD Protein Phosphorylation Skeletal Muscle Atrophy Negative Regulation Of Muscle Hypertrophy Myoblast Migration Involved In Skeletal Muscle Regeneration Response To Muscle Activity Ovulation Cycle Process Response To Testosterone Negative Regulation Of Kinase Activity Response To Estrogen Response To Ethanol Negative Regulation Of Myoblast Differentiation Positive Regulation Of Transcription, DNA-templated Negative Regulation Of Insulin Receptor Signaling Pathway Muscle Cell Cellular Homeostasis Negative Regulation Of Skeletal Muscle Tissue Growth Response To Electrical Stimulus Negative Regulation Of Protein Kinase B Signaling SMAD Protein Signal Transduction Cellular Response To Dexamethasone Stimulus Negative Regulation Of Skeletal Muscle Satellite Cell Proliferation Negative Regulation Of Satellite Cell Differentiation Negative Regulation Of Myoblast Proliferation
Pathways			FOXO-mediated transcription of cell cycle genes
Drugs			MYO-029
Diseases
GWAS		Age-related cognitive decline (attention/processing speed) (slope of z-scores) ( 30954325) Blood protein levels ( 29875488 28240269) Diverticular disease ( 30177863)	Daytime sleep phenotypes ( 27126917)
Interacting Genes		1 interacting genes: MSTN	6 interacting genes: ACVR2B APP FSTL3 SGTA TCAP WFIKKN2
Entrez ID		124857	2660
HPRD ID		18303	03474
Ensembl ID		ENSG00000173714	ENSG00000138379
Uniprot IDs		C9J6G4 Q8TEU8	O14793 Q53S46
PDB IDs			5F3B 5F3H 5NTU 5NXS 6UMX
Enriched GO Terms of Interacting Partners?
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