ISCA2 and RNF41

Data Source:
BioGRID (two hybrid)

		ISCA2	RNF41
Description		iron-sulfur cluster assembly 2	ring finger protein 41
Image		No pdb structure
GO Annotations	Cellular Component	Mitochondrion Mitochondrial Matrix	Cytosol Perinuclear Region Of Cytoplasm Endoplasmic Reticulum Tubular Network
	Molecular Function	Structural Molecule Activity Iron Ion Binding Protein Binding 2 Iron, 2 Sulfur Cluster Binding 4 Iron, 4 Sulfur Cluster Binding	Ubiquitin-protein Transferase Activity Erythropoietin Receptor Binding Interleukin-3 Receptor Binding Protein Binding Zinc Ion Binding Protein Domain Specific Binding Receptor Tyrosine Kinase Binding Small GTPase Binding Identical Protein Binding Ubiquitin Protein Ligase Activity
	Biological Process	Iron-sulfur Cluster Assembly Small Molecule Metabolic Process Protein Maturation By [4Fe-4S] Cluster Transfer	Protein Polyubiquitination Autophagy Negative Regulation Of Cell Population Proliferation Proteasomal Protein Catabolic Process Protein Ubiquitination Negative Regulation Of Cell Migration Regulation Of MAPK Cascade Regulation Of Lymphocyte Differentiation Regulation Of Myeloid Cell Differentiation Positive Regulation Of Protein Catabolic Process Positive Regulation Of DNA-binding Transcription Factor Activity Protein Autoubiquitination Regulation Of Protein Kinase B Signaling Extrinsic Apoptotic Signaling Pathway Negative Regulation Of Mitophagy Regulation Of Establishment Of Cell Polarity Regulation Of Reactive Oxygen Species Metabolic Process Positive Regulation Of Reactive Oxygen Species Metabolic Process
Pathways		Mitochondrial iron-sulfur cluster biogenesis	Downregulation of ERBB2:ERBB3 signaling Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS		Advanced glycation end-product levels ( 26915486)	Asthma ( 31619474)
Interacting Genes		8 interacting genes: ANKS1A EIF3E FAM124B GEM GUCD1 NTAQ1 RNF41 SUOX	42 interacting genes: ADRB2 AP2S1 APP ARL6IP4 ASB6 BIRC6 C1orf109 ENOPH1 ERBB3 ERBB4 IRS4 ISCA2 KDM3B LEPR LZTS2 MAGEL2 MARK2 MEOX2 MNAT1 MTNR1A MTNR1B MTURN N4BP3 RAD23A RFC4 RNF166 RRM2B SRR TCEANC TRIM32 TRIM8 TSG101 TTC1 UBASH3A UBASH3B UBE2D3 UBE2K UBE2U UBE2Z USP8 VPS52 ZAP70
Entrez ID		122961	10193
HPRD ID		17090	11520
Ensembl ID		ENSG00000165898	ENSG00000181852
Uniprot IDs		Q86U28	A0A024RB33 Q9H4P4
PDB IDs			2FZP 2GWF
Enriched GO Terms of Interacting Partners?
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