SOCS4 and MDFIC

Data Source:
BioGRID (two hybrid)

		SOCS4	MDFIC
Description		suppressor of cytokine signaling 4	MyoD family inhibitor domain containing
Image			No pdb structure
GO Annotations	Cellular Component	Phosphatidylinositol 3-kinase Complex	Nucleus Nucleolus Cytoplasm
	Molecular Function	Protein Binding 1-phosphatidylinositol-3-kinase Regulator Activity	Protein Binding Transcription Factor Binding Cyclin Binding Tat Protein Binding
	Biological Process	Negative Regulation Of Epidermal Growth Factor-activated Receptor Activity Protein Ubiquitination Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Intracellular Signal Transduction Regulation Of Growth Regulation Of Phosphatidylinositol 3-kinase Activity Phosphatidylinositol Phosphorylation	Activation Of JUN Kinase Activity Viral Process Regulation Of Wnt Signaling Pathway Negative Regulation Of Protein Import Into Nucleus Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Viral Transcription
Pathways		RUNX1 regulates transcription of genes involved in differentiation of keratinocytes
Drugs
Diseases
GWAS			Adventurousness ( 30643258) Body mass index ( 26426971 28892062) Clozapine-induced cytotoxicity ( 25656473) Drug experimentation measurement ( 30718321) General risk tolerance (MTAG) ( 30643258) Hip circumference ( 28552196) Midgestational circulating levels of PBDEs (fetal genetic effect) ( 28235828) Number of sexual partners ( 30643258) Obesity ( 23818313) Risk-taking tendency (4-domain principal component model) ( 30643258) Smoking status (ever vs never smokers) ( 30643258) Tonsillectomy ( 27182965 28928442)
Interacting Genes		11 interacting genes: CNMD EGFR LDHAL6B MDFIC NR4A1 PALS1 PLPP6 SPRY1 TEKT4 TNK2 VWF	4 interacting genes: CCNT1 CDK9 RPS6KA5 SOCS4
Entrez ID		122809	29969
HPRD ID		18084	17103
Ensembl ID		ENSG00000180008	ENSG00000135272
Uniprot IDs		Q5H9R6 Q8WXH5	Q9P1T7
PDB IDs		2IZV
Enriched GO Terms of Interacting Partners?
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