ADSS1 and TRMT61A

Data Source:
HPRD (two hybrid)

		ADSS1	TRMT61A
Description		adenylosuccinate synthase 1	tRNA methyltransferase 61A
Image
GO Annotations	Cellular Component	Cytoplasm Cytosol	Nucleus Nucleoplasm TRNA (m1A) Methyltransferase Complex
	Molecular Function	Magnesium Ion Binding GTPase Activity Adenylosuccinate Synthase Activity GTP Binding Phosphate Ion Binding Identical Protein Binding Actin Filament Binding	Protein Binding TRNA (adenine-N1-)-methyltransferase Activity MRNA (adenine-N1-)-methyltransferase Activity
	Biological Process	Immune System Process AMP Biosynthetic Process Aspartate Metabolic Process Glutamine Metabolic Process Purine Ribonucleoside Monophosphate Biosynthetic Process Response To Muscle Activity Cellular Response To Drug Response To Starvation 'de Novo' AMP Biosynthetic Process IMP Metabolic Process Cellular Response To Electrical Stimulus	TRNA Modification TRNA Methylation MRNA Methylation
Pathways		Purine ribonucleoside monophosphate biosynthesis	tRNA modification in the nucleus and cytosol
Drugs		Aspartic acid Hadacidin 6-O-Phosphoryl Inosine Monophosphate Guanosine-5'-Triphosphate Guanosine-5'-Diphosphate Adenylosuccinic acid Inosinic Acid Alanosine
Diseases
GWAS			Autism spectrum disorder or schizophrenia ( 28540026) Body mass index ( 26426971) Brain morphology (MOSTest) ( 32665545) Branched-chain amino acid levels (Isoleucine) ( 27898682) Extremely high intelligence ( 29520040) Hemoglobin levels ( 32327693) Intelligence (MTAG) ( 29326435) Mean corpuscular volume ( 32888494 27863252) Red blood cell count ( 32888494) Schizophrenia ( 25056061)
Interacting Genes		2 interacting genes: AZIN1 LYAR	2 interacting genes: TCL1A TRMT6
Entrez ID		122622	115708
HPRD ID		12433	08810
Ensembl ID		ENSG00000185100	ENSG00000166166
Uniprot IDs		B3KTV4 Q8N142	A0A024R6Q2 Q96FX7
PDB IDs		2GJO	5CCB 5CCX 5CD1
Enriched GO Terms of Interacting Partners?
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