ASCL4 and ID2

Data Source:
BioGRID (two hybrid)

		ASCL4	ID2
Description		achaete-scute family bHLH transcription factor 4	inhibitor of DNA binding 2
Image		No pdb structure
GO Annotations	Cellular Component	Chromatin Cellular_component RNA Polymerase II Transcription Regulator Complex	Euchromatin Nucleus Cytoplasm Cytosol Protein-containing Complex
	Molecular Function	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Protein Binding Protein Dimerization Activity	RNA Polymerase II Activating Transcription Factor Binding Protein Binding Ion Channel Binding Protein Dimerization Activity Transcription Regulator Activity Transcription Regulator Inhibitor Activity
	Biological Process	Regulation Of Transcription By RNA Polymerase II Skin Development	Negative Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Regulation Of Lipid Metabolic Process Cell Differentiation Circadian Regulation Of Gene Expression Mammary Gland Epithelial Cell Proliferation Regulation Of Circadian Rhythm Entrainment Of Circadian Clock By Photoperiod Negative Regulation Of DNA-binding Transcription Factor Activity Locomotor Rhythm Regulation Of Neuron Differentiation Positive Regulation Of Blood Pressure Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Embryonic Digestive Tract Morphogenesis Positive Regulation Of Smooth Muscle Cell Proliferation Neuron Fate Commitment Negative Regulation Of Muscle Cell Differentiation Mammary Gland Alveolus Development Epithelial Cell Differentiation Involved In Mammary Gland Alveolus Development Endodermal Digestive Tract Morphogenesis Positive Regulation Of Cell Cycle Arrest Positive Regulation Of Transcription Involved In G1/S Transition Of Mitotic Cell Cycle Cellular Senescence Regulation Of G1/S Transition Of Mitotic Cell Cycle Regulation Of Neural Precursor Cell Proliferation
Pathways			NGF-stimulated transcription
Drugs
Diseases
GWAS		Acne (severe) ( 24927181) Pelvic organ prolapse (moderate/severe) ( 26545240) Sleep duration ( 30846698)	Alcoholic chronic pancreatitis ( 28754779) Allergic rhinitis ( 30013184) Allergy ( 27182965) Asthma ( 31959851 27182965) Asthma (age of onset) ( 31036433) Asthma (childhood onset) ( 31036433) Cognitive decline rate in late mild cognitive impairment ( 26252872) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Electrocardiographic traits ( 32602732) IgE levels ( 22075330) Itch intensity from mosquito bite ( 28199695) Mean corpuscular volume ( 28017375) PR interval ( 29127183 30046033 32439900 31217584) Self-reported allergy ( 23817569)
Interacting Genes		7 interacting genes: CRK FHL3 ID2 MBD3 PDZD4 TCF12 TCF4	53 interacting genes: ADD1 ASB4 ASCL4 C22orf39 CDK2 DYRK1A DYRK1B ELK1 ELK3 ELK4 ELOC ENKD1 FANCL FNDC11 FRS3 GATA4 GFUS HES1 IFI16 KDM1A LRIF1 MAPK1 MAPK3 MAPK8 MSC MSGN1 MYF5 MYF6 MYOD1 MYOG NEDD9 NR0B2 PAX2 PAX5 PAX8 PICK1 PPP1CA PRMT6 RB1 RBL1 RBL2 RBM48 RHOU RIN3 SREBF1 SUV39H1 SUV39H2 TCF12 TCF3 TCF4 TCHP TNS2 UNC119
Entrez ID		121549	3398
HPRD ID		12374	02664
Ensembl ID		ENSG00000187855	ENSG00000115738
Uniprot IDs		Q6XD76	Q02363 Q53T66
PDB IDs			4AYA
Enriched GO Terms of Interacting Partners?
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