CLU and MMP25

Data Source:
HPRD (in vitro, in vivo)

		CLU	MMP25
Description		clusterin	matrix metallopeptidase 25
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Nucleus Cytoplasm Mitochondrion Mitochondrial Inner Membrane Golgi Apparatus Cytosol Cytoskeleton Cell Surface Membrane Platelet Alpha Granule Lumen Protein-containing Complex Spherical High-density Lipoprotein Particle Chromaffin Granule Intracellular Membrane-bounded Organelle Synapse Perinuclear Region Of Cytoplasm Collagen-containing Extracellular Matrix Extracellular Exosome Cell Periphery Blood Microparticle Neurofibrillary Tangle Apical Dendrite Perinuclear Endoplasmic Reticulum Lumen	Plasma Membrane Membrane Extracellular Matrix Anchored Component Of Membrane Specific Granule Membrane
	Molecular Function	Amyloid-beta Binding Signaling Receptor Binding Protein Binding ATPase Activity Ubiquitin Protein Ligase Binding Protein-containing Complex Binding Tau Protein Binding Low-density Lipoprotein Particle Receptor Binding Unfolded Protein Binding Chaperone Binding Misfolded Protein Binding	Metalloendopeptidase Activity Protein Binding Zinc Ion Binding
	Biological Process	Cell Morphogenesis Microglial Cell Activation Release Of Cytochrome C From Mitochondria Immune Complex Clearance Platelet Degranulation Lipid Metabolic Process Complement Activation Complement Activation, Classical Pathway Response To Virus Positive Regulation Of Gene Expression Protein Import Antimicrobial Humoral Response Regulation Of Complement Activation Negative Regulation Of Protein-containing Complex Assembly Positive Regulation Of Protein-containing Complex Assembly Central Nervous System Myelin Maintenance Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Tumor Necrosis Factor Production Regulation Of Cell Population Proliferation Regulation Of Apoptotic Process Positive Regulation Of Apoptotic Process Reverse Cholesterol Transport Innate Immune Response Positive Regulation Of Nitric Oxide Biosynthetic Process Positive Regulation Of Receptor-mediated Endocytosis Protein Stabilization Positive Regulation Of NF-kappaB Transcription Factor Activity Chaperone-mediated Protein Complex Assembly Response To Misfolded Protein Negative Regulation Of Cell Death Chaperone-mediated Protein Folding Microglial Cell Proliferation Protein Targeting To Lysosome Involved In Chaperone-mediated Autophagy Chaperone-mediated Protein Transport Involved In Chaperone-mediated Autophagy Negative Regulation Of Release Of Cytochrome C From Mitochondria Regulation Of Amyloid-beta Clearance Regulation Of Neuron Death Positive Regulation Of Neuron Death Positive Regulation Of Amyloid-beta Formation Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Negative Regulation Of Amyloid-beta Formation Regulation Of Neuronal Signal Transduction Positive Regulation Of Tau-protein Kinase Activity Positive Regulation Of Neurofibrillary Tangle Assembly Negative Regulation Of Response To Endoplasmic Reticulum Stress Negative Regulation Of Cellular Response To Thapsigargin Negative Regulation Of Cellular Response To Tunicamycin Negative Regulation Of Amyloid Fibril Formation Positive Regulation Of Amyloid Fibril Formation Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process	Proteolysis Inflammatory Response Extracellular Matrix Organization Collagen Catabolic Process Neutrophil Degranulation Hard Palate Development
Pathways		Platelet degranulation Terminal pathway of complement Antimicrobial peptides Regulation of Complement cascade	Activation of Matrix Metalloproteinases Neutrophil degranulation
Drugs		Zinc Copper Zinc acetate Zinc chloride Zinc sulfate, unspecified form	Marimastat Fenofibrate Fenofibric acid
Diseases
GWAS		Alzheimer's disease ( 19734902 19734903 21627779 31473137) Alzheimer's disease (late onset) ( 21460841 30617256 24162737 28714976) Alzheimer's disease in APOE e4+ carriers ( 25778476) Alzheimer's disease in APOE e4- carriers ( 25778476) Alzheimer's disease or family history of Alzheimer's disease ( 30617256) Alzheimer's disease or fasting insulin levels (pleiotropy) ( 30805717) anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028) Autism spectrum disorder or schizophrenia ( 28540026) Family history of Alzheimer's disease ( 30617256) Lung adenocarcinoma ( 28604730) Lung cancer in ever smokers ( 28604730) Panic disorder ( 19165232) Refractive error ( 32231278) Schizophrenia ( 25056061 29483656) Smoking behaviour (cigarettes smoked per day) ( 31089300) Smoking status (ever vs never smokers) ( 30643258) Spherical equivalent or myopia (age of diagnosis) ( 29808027)
Interacting Genes		50 interacting genes: APP BAG6 C7 C8B C9 CBY1 CD209 CLUAP1 CYP2E1 DISC1 ELN EPPIN FOS GRB2 HSPD1 IL24 KATNA1 KEAP1 KLF11 KNSTRN LEP LEPR LIG4 LRP2 LRP8 LYZ MAPK9 MDM2 MMP25 MSRB1 PAXIP1 PLXNA4 POLR1C PON1 PRNP RBBP8 RPL23 SRPK2 SYVN1 TGFBR1 TGFBR2 TNIK TREM2 TSC22D4 TTR UBC VHL VLDLR XRCC6 ZWINT	3 interacting genes: CLU MEOX2 MMP2
Entrez ID		1191	64386
HPRD ID		01706	07090
Ensembl ID		ENSG00000120885	ENSG00000008516
Uniprot IDs		P10909	Q9NPA2
PDB IDs
Enriched GO Terms of Interacting Partners?
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