CLCN6 and TNFRSF8

Data Source:
BioGRID (enzymatic study)

		CLCN6	TNFRSF8
Description		chloride voltage-gated channel 6	TNF receptor superfamily member 8
Image		No pdb structure
GO Annotations	Cellular Component	Lysosomal Membrane Endosome Membrane Integral Component Of Membrane Intracellular Membrane-bounded Organelle	Cytoplasm Plasma Membrane Integral Component Of Membrane Extracellular Exosome
	Molecular Function	Voltage-gated Chloride Channel Activity ATP Binding Chloride Transmembrane Transporter Activity Antiporter Activity	Transmembrane Signaling Receptor Activity
	Biological Process	Chloride Transport Cell Volume Homeostasis Signal Transduction Response To Mechanical Stimulus Ion Transmembrane Transport Chloride Transmembrane Transport	Signal Transduction Negative Regulation Of Cell Population Proliferation Positive Regulation Of TRAIL Production Positive Regulation Of Tumor Necrosis Factor Production Tumor Necrosis Factor-mediated Signaling Pathway Positive Regulation Of Apoptotic Process Cellular Response To Mechanical Stimulus
Pathways		Stimuli-sensing channels Signaling by BRAF and RAF fusions	TNFs bind their physiological receptors
Drugs			XmAb 2513 Brentuximab vedotin
Diseases
GWAS		Arterial stiffness index ( 31235810) Coronary artery disease ( 29212778) Diastolic blood pressure ( 29615537) Diastolic blood pressure (cigarette smoking interaction) ( 29455858) Diastolic blood pressure x alcohol consumption (light vs heavy) interaction (2df test) ( 29912962) Diastolic blood pressure x alcohol consumption interaction (2df test) ( 29912962) Diastolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Diastolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Mean arterial pressure x alcohol consumption (light vs heavy) interaction (2df test) ( 29912962) Mean arterial pressure x alcohol consumption interaction (2df test) ( 29912962) Mean corpuscular hemoglobin ( 27863252) Mean corpuscular volume ( 27863252) Medication use (agents acting on the renin-angiotensin system) ( 31015401) Medication use (beta blocking agents) ( 31015401) Medication use (diuretics) ( 31015401) Natriuretic peptide levels ( 21273288) Pulse pressure x alcohol consumption interaction (2df test) ( 29912962) Red cell distribution width ( 32888494) Systolic blood pressure ( 19430483 29615537 30578418) Systolic blood pressure (cigarette smoking interaction) ( 29455858) Systolic blood pressure x alcohol consumption (light vs heavy) interaction (2df test) ( 29912962) Systolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Systolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858) Testicular germ cell tumor ( 28604728) Tuberculosis ( 29036319)	Asthma ( 31959851 32296059) Eosinophil counts ( 32888494 27863252) Eosinophil percentage of granulocytes ( 27863252) Eosinophil percentage of white cells ( 32888494 27863252) Mosquito bite size ( 28199695) Neutrophil percentage of granulocytes ( 27863252) Sum eosinophil basophil counts ( 27863252) Tuberculosis ( 29036319)
Interacting Genes		1 interacting genes: ERBB2	7 interacting genes: ALK TDP2 TNFSF8 TRAF1 TRAF2 TRAF3 TRAF5
Entrez ID		1185	943
HPRD ID		04102	01074
Ensembl ID		ENSG00000011021	ENSG00000120949
Uniprot IDs		P51797	A5D8T4 P28908
PDB IDs			1D01
Enriched GO Terms of Interacting Partners?
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