CLCN5 and WWP2

Data Source:
HPRD (in vitro)

		CLCN5	WWP2
Description		chloride voltage-gated channel 5	WW domain containing E3 ubiquitin protein ligase 2
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GO Annotations	Cellular Component	Golgi Membrane Lysosomal Membrane Early Endosome Golgi Apparatus Cytosol Plasma Membrane Integral Component Of Plasma Membrane Synaptic Vesicle Endosome Membrane Membrane Apical Part Of Cell	Ubiquitin Ligase Complex Nucleus Cytoplasm Cytosol Membrane Extracellular Exosome
	Molecular Function	Voltage-gated Chloride Channel Activity Chloride Channel Activity Protein Binding ATP Binding Solute:proton Antiporter Activity Identical Protein Binding	RNA Polymerase II Transcription Factor Binding Ubiquitin-protein Transferase Activity Protein Binding Transcription Factor Binding Ubiquitin Protein Ligase Activity
	Biological Process	Endocytosis Excretion Ion Transmembrane Transport Chloride Transmembrane Transport Proton Transmembrane Transport	Negative Regulation Of Transcription By RNA Polymerase II Protein Polyubiquitination Cellular Protein Modification Process Extracellular Transport Negative Regulation Of Gene Expression Protein Ubiquitination Negative Regulation Of Transporter Activity Regulation Of Ion Transmembrane Transport Regulation Of Membrane Potential Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of DNA-binding Transcription Factor Activity Positive Regulation Of Protein Catabolic Process Negative Regulation Of Notch Signaling Pathway Negative Regulation Of Transcription, DNA-templated Viral Entry Into Host Cell Negative Regulation Of Protein Transport Protein Autoubiquitination Protein K63-linked Ubiquitination Regulation Of Potassium Ion Transmembrane Transporter Activity
Pathways		Stimuli-sensing channels	Regulation of PTEN stability and activity NOTCH3 Activation and Transmission of Signal to the Nucleus
Drugs
Diseases		Dent disease, including: Dent disease 1; Dent disease 2; X-linked recessive nephrolithiasis ; Hypophosphatemic rickets; Low-molecular-weight proteinuria with hypercalciuria and nephrocalcinosis
GWAS		Height ( 28552196) Hip circumference adjusted for BMI ( 28552196) Red blood cell count ( 32888494)	Body fat distribution (arm fat ratio) ( 30664634) Body fat distribution (leg fat ratio) ( 30664634) Body mass index ( 26426971) Brain morphology (MOSTest) ( 32665545) Cataracts (operation) ( 31816047) Diastolic blood pressure ( 30578418) Diverticular disease ( 30177863) Estimated glomerular filtration rate ( 31152163) FEV1 ( 30804560) Hand grip strength ( 29691431) Height ( 28552196 31562340) IgE levels ( 23146381) Knee osteoarthritis ( 30374069) Low density lipoprotein cholesterol levels ( 32154731) Lung function (FVC) ( 30804560) Lung function in never smokers (low FEV1 vs high FEV1) ( 26423011) Menarche (age at onset) ( 25231870) Plantar fascial disorders ( 29534260) Platelet count ( 32888494) Pulse pressure ( 30578418) Smoking behaviour (cigarette pack-years) ( 30679032) Triglyceride levels ( 31928498) Triglycerides ( 30275531) Waist circumference ( 31928498)
Interacting Genes		4 interacting genes: CFL1 MAGI1 WWP1 WWP2	79 interacting genes: ANKRD44 ARRDC1 ARRDC3 ATN1 CDC34 CLCN5 CPSF6 DAG1 DIDO1 EFCAB3 EGR2 EWSR1 FAM189A2 FAM214B FBXL18 GADD45GIP1 GAS2L2 GGN GRAP2 HNRNPUL1 IFIT2 IL2RG IL6R LGALS9B MED25 MIR19A MIR19B1 MIR92A1 NDFIP1 NDFIP2 PAIP1 PATZ1 PDLIM7 PRKAA2 PSMF1 RASA1 RASD1 RNF11 RUSC1 SCAMP3 SCN5A SCNN1A SCNN1B SCNN1G SEC24D SF1 SFTPC SLC9A3R2 SMAD3 SMAD7 SMARCD1 SMR3A SNRPB SNRPC SPART TFAP2A TNK2 TP53BP2 TRAF4 UBC UBE2D1 UBE2D2 UBE2D3 UBE2E1 UBE2E2 UBE2E3 UBE2I UBE2J2 UBE2K UBE2L3 UBTD1 USP7 VASP VPS37C WBP1 WBP2 WDR5 WIPF1 ZNF688
Entrez ID		1184	11060
HPRD ID		02053	03812
Ensembl ID		ENSG00000171365	ENSG00000198373
Uniprot IDs		A8K4H5 B3KRR2 P51795 V9GYG7	A0A024R711 B4DHF6 O00308
PDB IDs		2J9L 2JA3	4Y07 5TJ7 5TJ8 5TJQ 6J1Z 6RSS
Enriched GO Terms of Interacting Partners?
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