SLC16A10 and INSIG2

Data Source:
BioGRID (two hybrid)

		SLC16A10	INSIG2
Description		solute carrier family 16 member 10	insulin induced gene 2
Image		No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane Integral Component Of Membrane Basolateral Plasma Membrane Cell Junction Intracellular Membrane-bounded Organelle	Endoplasmic Reticulum Endoplasmic Reticulum Membrane SREBP-SCAP-Insig Complex
	Molecular Function	Protein Binding Amino Acid Transmembrane Transporter Activity Aromatic Amino Acid Transmembrane Transporter Activity Thyroid Hormone Transmembrane Transporter Activity	Protein Binding Oxysterol Binding
	Biological Process	Amino Acid Transmembrane Transport Thyroid Hormone Generation Amino Acid Transport Aromatic Amino Acid Transport Thyroid Hormone Transport Thyroid-stimulating Hormone Secretion	Cholesterol Biosynthetic Process Sterol Biosynthetic Process Cellular Response To Insulin Stimulus SREBP Signaling Pathway SREBP-SCAP Complex Retention In Endoplasmic Reticulum
Pathways		Amino acid transport across the plasma membrane	Regulation of cholesterol biosynthesis by SREBP (SREBF)
Drugs
Diseases
GWAS		Amino acid levels ( 26068415) Bisphosphonate-associated atypical femoral fracture ( 31006051) Blood metabolite levels ( 24816252) Inflammatory bowel disease ( 28067908) Mean corpuscular hemoglobin ( 32888494 27863252) Mean corpuscular volume ( 32888494 27863252) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Metabolic traits ( 21886157) Metabolite levels ( 23823483 22286219) Metabolite levels (small molecules and protein measures) ( 27005778) Refractive error ( 32231278) Tyrosine levels ( 31560688) Ulcerative colitis ( 28067908)	Apolipoprotein B levels ( 32203549) Cholesterol, total ( 24097068) Depression in response to interferon-based therapy in chronic hepatitis C ( 27723809) Heel bone mineral density ( 30598549 28869591) LDL cholesterol ( 24097068 30275531) LDL cholesterol levels ( 32203549 30698716) LDL cholesterol levels in current drinkers ( 30698716) LDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) LDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Low density lipoprotein cholesterol levels ( 32154731) Lumbar spine bone mineral density ( 22504420) Monobrow ( 27182965) Mosquito bite size ( 28199695) Total cholesterol levels ( 30275531)
Interacting Genes		4 interacting genes: FUNDC2 INSIG2 RACGAP1 TMEM14B	46 interacting genes: ABHD4 AQP2 AQP6 ATP6V0B BIK CD40 CD79A CPLX4 CREB3L1 CYBC1 EBP FAM209A GJA8 GOLM1 GPR152 GPR37L1 GPX8 HSD17B13 IFNGR2 KIR2DL3 LAPTM5 LHFPL5 LMNA MMGT1 MUC1 NEMP1 PRLR PSCA PSMA7 PSMB1 PSMC3 PSMC5 PVR RNF5 SCAP SCN3B SLC16A10 SREBF2 STIM1 TMEM14B TMEM237 TMEM45B TMEM52B TMX2 VCP VMA21
Entrez ID		117247	51141
HPRD ID		09613	16361
Ensembl ID		ENSG00000112394	ENSG00000125629
Uniprot IDs		Q8TF71	A0A024RAI2 B4DQ23 Q9Y5U4
PDB IDs			4J82
Enriched GO Terms of Interacting Partners?
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