MED12L and CKS1B

Data Source:
BioGRID (two hybrid)

		MED12L	CKS1B
Description		mediator complex subunit 12L	CDC28 protein kinase regulatory subunit 1B
Image		No pdb structure
GO Annotations	Cellular Component	Mediator Complex	Cyclin-dependent Protein Kinase Holoenzyme Complex Nucleoplasm SCF Ubiquitin Ligase Complex
	Molecular Function	Transcription Coactivator Activity Protein Binding Beta-catenin Binding Transcription Factor Binding	Protein Binding Protein Kinase Binding Histone Binding Ubiquitin Binding Cyclin-dependent Protein Serine/threonine Kinase Activator Activity
	Biological Process	Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Transcription, DNA-templated	Regulation Of Transcription, DNA-templated Regulation Of Mitotic Cell Cycle Cell Population Proliferation Mitotic Cell Cycle Phase Transition Positive Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Cell Division
Pathways			SCF(Skp2)-mediated degradation of p27/p21 Cyclin D associated events in G1
Drugs			Fluoxetine 2,8-bis[oxido(oxo)vanadio]-1,1,1,3,5,5,7,7,9,9,9-undecaoxopentavanadoxane-2,8-diium
Diseases
GWAS		Chronotype ( 30696823) Eosinophil counts ( 32888494) Epstein-Barr virus EBNA-1 antibody levels ( 33204752) Heschl's gyrus morphology ( 25130324) Lymphocyte counts ( 32888494) Monocyte count ( 32888494) Parkinson's disease ( 32201043) Parkinson's disease or first degree relation to individual with Parkinson's disease ( 31701892) Trunk fat mass ( 28552196) White blood cell count ( 32888494)	Bipolar disorder ( 31043756) Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Prostate cancer ( 23535732)
Interacting Genes		7 interacting genes: AR CKS1B LAMTOR5 MAPK9 MSRB3 TLE5 TTC23	59 interacting genes: ARID5A CBY2 CCDC120 CCNA1 CCNB2 CCNC CDC27 CDC37 CDK2 CDK3 CDKN1B CDX4 CKS1BP7 CKS2 CT45A1 CUL1 DCDC2 DUSP1 ECPAS GAS8 HSF2BP HSP90AA1 IKZF1 IKZF3 INCA1 KPRP KRTAP10-9 KRTAP5-9 LDHB LHX3 LZTS1 MED12L MEOX1 MEOX2 MIPOL1 NR5A1 PAX5 PAX6 PPP1R13B PSMD9 REL ROPN1 SEPTIN3 SERTAD1 SERTAD2 SKP2 SNRNP35 SPDYE4 SSBP1 SUMO1P1 TCF12 TCF4 TRIM14 TRIM27 TRIM49 TRIM49C WASF3 XIAP ZBTB9
Entrez ID		116931	1163
HPRD ID		10278	00299
Ensembl ID		ENSG00000144893	ENSG00000173207
Uniprot IDs		B3KXY0 Q86YW9	P61024 Q5T178
PDB IDs			1BUH 1DKS 1DKT 2ASS 2AST 4YC6
Enriched GO Terms of Interacting Partners?
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