TSEN15 and PLB1

Data Source:
BioGRID (two hybrid)

		TSEN15	PLB1
Description		tRNA splicing endonuclease subunit 15	phospholipase B1
Image			No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Nucleolus	Plasma Membrane Integral Component Of Membrane Apical Plasma Membrane Brush Border Membrane
	Molecular Function	Nucleic Acid Binding Nuclease Activity Protein Binding	Phospholipase Activity Lysophospholipase Activity Phospholipase A2 Activity Triglyceride Lipase Activity Retinyl-palmitate Esterase Activity Phosphatidyl Phospholipase B Activity Phospholipase A2 Activity (consuming 1,2-dipalmitoylphosphatidylcholine) Phospholipase A2 Activity Consuming 1,2-dioleoylphosphatidylethanolamine)
	Biological Process	TRNA Splicing, Via Endonucleolytic Cleavage And Ligation MRNA Processing Nucleic Acid Phosphodiester Bond Hydrolysis	Retinoid Metabolic Process Phospholipid Metabolic Process Phosphatidylcholine Acyl-chain Remodeling Retinol Metabolic Process Positive Regulation Of Acrosome Reaction
Pathways		tRNA processing in the nucleus	Acyl chain remodelling of PC Retinoid metabolism and transport
Drugs
Diseases
GWAS		Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Chronotype ( 30696823) Height ( 20881960) Hip circumference adjusted for BMI ( 25673412) Hippocampal volume in Alzheimer's disease dementia ( 29274321) Type 2 diabetes ( 32499647) Waist circumference adjusted for BMI (adjusted for smoking behaviour) ( 28443625) Waist circumference adjusted for BMI (joint analysis main effects and physical activity interaction) ( 28448500) Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction) ( 28443625) Waist circumference adjusted for BMI in active individuals ( 28448500) Waist circumference adjusted for BMI in inactive individuals ( 28448500) Waist circumference adjusted for BMI in non-smokers ( 28443625) Waist circumference adjusted for body mass index ( 28552196 25673412)	Allergic disease (asthma, hay fever and/or eczema) (age of onset) ( 32603359) Allergic disease (asthma, hay fever and/or eczema) (multivariate analysis) ( 32603359) Chronic obstructive pulmonary disease or resting heart rate (pleiotropy) ( 30940143) Eosinophil counts ( 32888494 27863252) Eosinophil percentage of granulocytes ( 27863252) Eosinophil percentage of white cells ( 32888494 27863252) Excessive sweating ( 29895819) Heel bone mineral density ( 30598549) Intracranial aneurysm ( 29531279) Neutrophil percentage of granulocytes ( 27863252) Proportion of activated microglia (inferior temporal cortex) ( 30679421) Sum eosinophil basophil counts ( 27863252) Triglyceride levels in current drinkers ( 30698716) Triglyceride levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) Triglyceride levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716)
Interacting Genes		34 interacting genes: AIF1L ARID5A ASB12 CCDC33 DDIT4L DNAAF6 ENKD1 ERBB2 EXOSC4 GORASP2 HSF2BP IKZF3 INCA1 LMO2 LMO4 LRIF1 MEI4 MIPOL1 NBPF3 PBX4 PHOSPHO2 PLB1 POLR2G POU6F2 REL TASOR2 TEPSIN TLE5 TSEN34 TSSK2 USP54 ZMAT2 ZNF554 ZNF620	8 interacting genes: FRS3 HSF2BP NLGN3 PIK3R3 RIN3 S100A1 TNS2 TSEN15
Entrez ID		116461	151056
HPRD ID		12292	15141
Ensembl ID		ENSG00000198860	ENSG00000163803
Uniprot IDs		A0A2U3TZM3 B1ALV0 E9PPN1 Q8WW01	B2RWP8 Q6P1J6
PDB IDs		2GW6
Enriched GO Terms of Interacting Partners?
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