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TLCD1 and CD40
Data Source:
BioGRID
(two hybrid)
TLCD1
CD40
Description
TLC domain containing 1
CD40 molecule
Image
No pdb structure
GO Annotations
Cellular Component
Plasma Membrane
Integral Component Of Membrane
Cytoplasm
Plasma Membrane
Integral Component Of Plasma Membrane
External Side Of Plasma Membrane
Cell Surface
CD40 Receptor Complex
Neuronal Cell Body
Varicosity
Intracellular Membrane-bounded Organelle
Extracellular Exosome
Molecular Function
Protein Binding
Antigen Binding
Protein Binding
Enzyme Binding
Protein Domain Specific Binding
Ubiquitin Protein Ligase Binding
Signaling Receptor Activity
Biological Process
Plasma Membrane Organization
Lipid Homeostasis
Phospholipid Homeostasis
Membrane Assembly
Regulation Of Membrane Lipid Distribution
Positive Regulation Of Protein Phosphorylation
Immune Response-regulating Cell Surface Receptor Signaling Pathway
Cellular Calcium Ion Homeostasis
Inflammatory Response
CD40 Signaling Pathway
Platelet Activation
Positive Regulation Of B Cell Proliferation
Positive Regulation Of Interleukin-12 Production
Tumor Necrosis Factor-mediated Signaling Pathway
Response To Cobalamin
Response To Interferon-gamma
TRIF-dependent Toll-like Receptor Signaling Pathway
Cellular Response To Erythropoietin
B Cell Proliferation
B Cell Activation
Positive Regulation Of Tyrosine Phosphorylation Of STAT Protein
Defense Response To Protozoan
Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling
Positive Regulation Of MAP Kinase Activity
Protein Kinase B Signaling
Positive Regulation Of Blood Vessel Endothelial Cell Migration
Positive Regulation Of GTPase Activity
Positive Regulation Of Angiogenesis
Positive Regulation Of Transcription By RNA Polymerase II
Positive Regulation Of Isotype Switching To IgG Isotypes
Regulation Of Immune Response
Positive Regulation Of NF-kappaB Transcription Factor Activity
Defense Response To Virus
Protein-containing Complex Assembly
Cellular Response To Lipopolysaccharide
Cellular Response To Mechanical Stimulus
Cellular Response To Interleukin-1
Cellular Response To Tumor Necrosis Factor
Positive Regulation Of Protein Kinase C Signaling
Response To Peptide
Positive Regulation Of Endothelial Cell Apoptotic Process
Pathways
Drugs
Lucatumumab
Dacetuzumab
Diseases
Hyper IgM syndromes, autosomal recessive type, including the following three diseases: Activation-induced cytidine deaminase (AICD) defect; Uracil nucleotide glycoside glycosylase (UNG) defect; Immunodeficiency with hyper-IgM type 3
Combined immunodeficiencies (CIDs), including the following nine diseases: X-linked hyper IgM syndrome; CD40 deficiency hyper IgM syndrome; Purine nucleoside phosphorylase (PNP) deficiency; Omenn syndrome; MHC deficiency (HLA-class I); MHC deficiency (HLA-class II); Zap-70 deficiency; p56 Lck deficiency; CD8 deficiency
GWAS
Blood protein levels in cardiovascular risk (
28369058
)
Chronic hepatitis B infection (
25802187
)
Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) (
26974007
)
Crohn's disease (
28067908
)
Hodgkin's lymphoma (
30194254
)
Inflammatory bowel disease (
28067908
23128233
)
Kawasaki disease (
22446961
33106546
22446962
)
Multiple sclerosis (
22190364
24076602
19525955
21833088
)
Rheumatoid arthritis (
30423114
18794853
23143596
24390342
20453842
)
Rheumatoid arthritis (ACPA-positive) (
23143596
24532676
)
Systemic lupus erythematosus (
28714469
)
Tonsillectomy (
27182965
28928442
)
Interacting Genes
8 interacting genes:
AQP6
CD40
CREB3L1
EBP
FXYD3
SSMEM1
TMEM14B
TMEM80
44 interacting genes:
BIRC2
BIRC3
CAV1
CBL
CD40LG
CMTM5
CMTM6
CYB561A3
DEFB121
EBP
FAF1
HSPA4
HSPA8
IL4R
INSIG2
JAK3
MAL
MAP3K8
MFSD5
MIP
MS4A1
NCOA6
NSMAF
PIK3R1
PLP1
RIPK2
SLC30A2
SLC30A3
SLC39A13
SLC7A1
TANK
TDP2
TLCD1
TMEM107
TMEM128
TMEM147
TRAF1
TRAF2
TRAF3
TRAF3IP2
TRAF5
TRAF6
XRCC5
XRCC6
Entrez ID
116238
958
HPRD ID
14015
00178
Ensembl ID
ENSG00000160606
ENSG00000101017
Uniprot IDs
Q96CP7
A0A0S2Z349
A0A0S2Z3C7
P25942
Q6P2H9
PDB IDs
1CDF
1CZZ
1D00
1FLL
1LB6
3QD6
5DMI
5DMJ
5IHL
6FAX
6PE8
6PE9
Enriched GO Terms of Interacting Partners
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Tagcloud
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Tagcloud (Difference)
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Tagcloud (Intersection)
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