TGM7 and TNXB

Data Source:
BioGRID (two hybrid)

		TGM7	TNXB
Description		transglutaminase 7	tenascin XB
Image		No pdb structure
GO Annotations	Cellular Component		Extracellular Region Extracellular Space Extracellular Matrix Collagen-containing Extracellular Matrix Extracellular Exosome
	Molecular Function	Protein-glutamine Gamma-glutamyltransferase Activity Protein Binding Metal Ion Binding	Integrin Binding Extracellular Matrix Structural Constituent Protein Binding Heparin Binding Collagen Fibril Binding
	Biological Process	Peptide Cross-linking Protein Phosphopantetheinylation	Cell Adhesion Actin Cytoskeleton Organization Collagen Fibril Organization Collagen Metabolic Process Elastic Fiber Assembly
Pathways			ECM proteoglycans
Drugs
Diseases			Ehlers-Danlos syndrome (EDS), including: EDS classical type (EDS1/2); EDS hypermobility type (EDS3); EDS vascular type (EDS4); EDS kyphoscoliosis type (EDS6); EDS arthrochalasia type (EDS7A/7B); EDS dermatospraxis type (EDS7C); EDS autosomal recessive cardiac valvular form (EDSCV); EDS musculocontractural type (EDSMC); EDS progeroid form (EDSP); Tenascin-X deficiency (TNXD); Brittle cornea syndrome (EDS6B); EDS-like spondylocheiro dysplasia (SCD-EDS)
GWAS			Age-related macular degeneration ( 22694956) Alzheimer's disease ( 30636644) Asthma ( 31619474) Atopic dermatitis ( 23886662) Autism spectrum disorder or schizophrenia ( 28540026) Automobile speeding propensity ( 30643258) Blood protein levels ( 29875488 28240269) Coronary artery disease ( 32469254) Diastolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Diastolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858) Eosinophil counts ( 27863252) Hemoglobin levels ( 32327693) HIV-1 control ( 20041166) Inflammatory bowel disease ( 28067908) Intraocular pressure ( 29617998 30054594) Lung cancer ( 28604730) Lung cancer in ever smokers ( 28604730) Mean corpuscular volume ( 32888494 27863252) Mean spheric corpuscular volume ( 32888494) Metabolite levels ( 23823483) Neutrophil count ( 32888494) Plasma omega-3 polyunsaturated fatty acid levels (docosapentaenoic acid) ( 21829377) Platelet distribution width ( 32888494) Prostate cancer ( 23535732) Refractive error ( 32231278) Sarcoidosis (non-Lofgren's syndrome without extrapulmonary manifestations) ( 26651848) Schizophrenia ( 30285260) Shingles ( 28928442) Squamous cell lung carcinoma ( 28604730) Sum eosinophil basophil counts ( 27863252) Systemic lupus erythematosus ( 26316170 26502338 21408207 28714469) Systolic blood pressure ( 28739976) Systolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Systolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858) Type 1 diabetes and autoimmune thyroid diseases ( 25936594) Ulcerative colitis ( 28067908) White blood cell count ( 32888494 27863252)
Interacting Genes		20 interacting genes: ARID5A CDSN FRS3 GEM HNRNPF HOXA1 KCTD1 KRT39 LAMTOR3 LNX1 PPP1R32 PRKAB2 QARS1 SDS SPATA18 SPRY1 TNXB TSSK3 UNKL YPEL3	6 interacting genes: BANP CEACAM6 POU6F2 TGM7 VEGFA VEGFB
Entrez ID		116179	7148
HPRD ID		09485	02993
Ensembl ID		ENSG00000159495	ENSG00000168477
Uniprot IDs		Q96PF1	O95680 O95681 P22105 Q6IPK3 Q9Y464
PDB IDs			2CUH 2CUI 2CUM
Enriched GO Terms of Interacting Partners?
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