TRMT61A and PLD4

Data Source:
BioGRID (two hybrid)

		TRMT61A	PLD4
Description		tRNA methyltransferase 61A	phospholipase D family member 4
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm TRNA (m1A) Methyltransferase Complex	Nucleus Early Endosome Endoplasmic Reticulum Endoplasmic Reticulum Membrane Integral Component Of Membrane Trans-Golgi Network Membrane Phagocytic Vesicle
	Molecular Function	Protein Binding TRNA (adenine-N1-)-methyltransferase Activity MRNA (adenine-N1-)-methyltransferase Activity	Phospholipase D Activity Single-stranded DNA 5'-3' Exodeoxyribonuclease Activity
	Biological Process	TRNA Modification TRNA Methylation MRNA Methylation	Hematopoietic Progenitor Cell Differentiation DNA Metabolic Process Phagocytosis Inflammatory Response Inositol Phosphate Metabolic Process Innate Immune Response Nucleic Acid Phosphodiester Bond Hydrolysis Regulation Of Cytokine Production Involved In Inflammatory Response
Pathways		tRNA modification in the nucleus and cytosol	Synthesis of PG Synthesis of IP3 and IP4 in the cytosol Role of phospholipids in phagocytosis
Drugs
Diseases
GWAS		Autism spectrum disorder or schizophrenia ( 28540026) Body mass index ( 26426971) Brain morphology (MOSTest) ( 32665545) Branched-chain amino acid levels (Isoleucine) ( 27898682) Extremely high intelligence ( 29520040) Hemoglobin levels ( 32327693) Intelligence (MTAG) ( 29326435) Mean corpuscular volume ( 32888494 27863252) Red blood cell count ( 32888494) Schizophrenia ( 25056061)	Cerebrospinal fluid t-tau levels ( 29274321) Cerebrospinal fluid t-tau levels in normal cognition ( 29274321) Rheumatoid arthritis ( 30423114 22446963 24390342)
Interacting Genes		2 interacting genes: TCL1A TRMT6
Entrez ID		115708	122618
HPRD ID		08810	11230
Ensembl ID		ENSG00000166166	ENSG00000166428
Uniprot IDs		A0A024R6Q2 Q96FX7	A0A3B3IT68 B4DI07 B4DJQ6 F5H2B5 Q96BZ4
PDB IDs		5CCB 5CCX 5CD1
Enriched GO Terms of Interacting Partners?
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