MALSU1 and CHMP2B

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		MALSU1	CHMP2B
Description		mitochondrial assembly of ribosomal large subunit 1	charged multivesicular body protein 2B
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GO Annotations	Cellular Component	Mitochondrion Mitochondrial Large Ribosomal Subunit Cytosol	ESCRT III Complex Cytoplasm Lysosome Endosome Late Endosome Multivesicular Body Cytosol Plasma Membrane Late Endosome Membrane Extracellular Exosome
	Molecular Function	Protein Binding Ribosomal Large Subunit Binding	Protein Binding Protein Domain Specific Binding Cadherin Binding
	Biological Process	Negative Regulation Of Translation Ribosomal Large Subunit Biogenesis Negative Regulation Of Mitochondrial Translation Negative Regulation Of Ribosome Biogenesis	Autophagy Nucleus Organization Endosome Organization Mitotic Metaphase Plate Congression Regulation Of Centrosome Duplication Protein Transport Endosomal Transport Macroautophagy Viral Life Cycle Endosome Transport Via Multivesicular Body Sorting Pathway Multivesicular Body Assembly Viral Budding Via Host ESCRT Complex Late Endosome To Vacuole Transport Cognition Multivesicular Body-lysosome Fusion Midbody Abscission Neuron Cellular Homeostasis Regulation Of Mitotic Spindle Assembly Positive Regulation Of Viral Release From Host Cell ESCRT III Complex Disassembly
Pathways			Budding and maturation of HIV virion Macroautophagy Endosomal Sorting Complex Required For Transport (ESCRT) HCMV Late Events Late endosomal microautophagy Sealing of the nuclear envelope (NE) by ESCRT-III Translation of Replicase and Assembly of the Replication Transcription Complex Translation of Replicase and Assembly of the Replication Transcription Complex
Drugs
Diseases			Frontotemporal lobar degeneration (FTLD), including: Pick disease of brain; Frontotemporal dementia (FTD); Ubiquitin-positive frontotemporal dementia (UP-FTD); Progressive supranuclear palsy type 1 (PSNP1); Inclusion body myopathy with early-onset paget disease and frontotemporal dementia (IBMPFD); Frontotemporal dementia, chromosome 3-linked (FTD3)
GWAS		Iron status biomarkers (transferrin saturation) ( 28334935)	Tourette's syndrome or obsessive-compulsive disorder ( 25158072)
Interacting Genes		13 interacting genes: CHMP2B DCTD INCA1 LMO3 MEOX2 MYBPHL NTAQ1 PLEKHG4 SP6 TRIM55 TRIM63 ZFP90 ZNF426	12 interacting genes: ATP5F1C CENPF CHMP3 DPY30 FBXO7 MALSU1 PHGDH PNMA1 TERF2IP TRAF2 USP54 USP8
Entrez ID		115416	25978
HPRD ID		12918	13174
Ensembl ID		ENSG00000156928	ENSG00000083937
Uniprot IDs		Q96EH3	B2RE76 Q9UQN3
PDB IDs		5OOL 5OOM	2JQK
Enriched GO Terms of Interacting Partners?
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