CGAS and RNF185

Data Source:
BioGRID (affinity chromatography technology, enzymatic study)

		CGAS	RNF185
Description		cyclic GMP-AMP synthase	ring finger protein 185
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Cytosol Plasma Membrane Site Of Double-strand Break	Mitochondrial Outer Membrane Endoplasmic Reticulum Endoplasmic Reticulum Membrane Integral Component Of Membrane Endoplasmic Reticulum Quality Control Compartment
	Molecular Function	DNA Binding Chromatin Binding Double-stranded DNA Binding Protein Binding ATP Binding GTP Binding Phosphatidylinositol-4,5-bisphosphate Binding Metal Ion Binding Cyclic-GMP-AMP Synthase Activity	Protein Binding Ubiquitin Binding Ubiquitin-like Protein Conjugating Enzyme Binding Protein-containing Complex Binding Metal Ion Binding Ubiquitin Protein Ligase Activity
	Biological Process	Activation Of Innate Immune Response Positive Regulation Of Defense Response To Virus By Host Regulation Of Immunoglobulin Production DNA Repair Cellular Response To DNA Damage Stimulus Determination Of Adult Lifespan Positive Regulation Of CGMP-mediated Signaling Viral Process Positive Regulation Of Type I Interferon Production Paracrine Signaling Positive Regulation Of CAMP-mediated Signaling Innate Immune Response Regulation Of T Cell Activation Defense Response To Virus Cellular Response To Exogenous DsRNA Negative Regulation Of Double-strand Break Repair Via Homologous Recombination Positive Regulation Of Cellular Senescence	Ubiquitin-dependent Protein Catabolic Process Autophagy Ubiquitin-dependent ERAD Pathway ERAD Pathway Protein Autoubiquitination Transmembrane Transport ER-associated Misfolded Protein Catabolic Process Positive Regulation Of ERAD Pathway Endoplasmic Reticulum Mannose Trimming
Pathways		STING mediated induction of host immune responses	ABC-family proteins mediated transport Defective CFTR causes cystic fibrosis ER Quality Control Compartment (ERQC)
Drugs
Diseases
GWAS			Apolipoprotein A1 levels ( 32203549) Fish- and plant-related diet ( 32066663) Oily fish consumption ( 32066663) Pork consumption ( 32066663) Waist circumference ( 28552196) White blood cell count ( 32888494)
Interacting Genes		1 interacting genes: RNF185	32 interacting genes: APP CGAS CMTM5 CYB561A3 DVL2 FAM241B MALL MS4A13 MTNR1B MYADML2 NIPAL4 RNF5 TMBIM6 TMEM147 TMEM19 TMEM86A UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2E1 UBE2E2 UBE2E3 UBE2H UBE2I UBE2K UBE2V1 UBE2W USP21 YIPF2 YIPF4 YIPF6
Entrez ID		115004	91445
HPRD ID		12857	08790
Ensembl ID		ENSG00000164430	ENSG00000138942
Uniprot IDs		Q8N884	A0A024R1F5 A0A024R1H4 Q96GF1
PDB IDs		4KM5 4LEV 4LEW 4MKP 4O67 4O68 4O69 5V8O 5VDO 5VDP 5VDQ 5VDR 5VDS 5VDT 5VDU 5VDV 5VDW 6CT9 6CTA 6EDB 6EDC 6LRC 6LRE 6LRI 6LRJ 6LRK 6LRL 6MJU 6MJW 6MJX 6NAO 6NFG 6NFO 6O47 6Y5D 6Y5E 7C0M 7CCQ 7CCR
Enriched GO Terms of Interacting Partners?
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