C1QTNF1 and AVPR2

Data Source:
HPRD (two hybrid, in vitro)

		C1QTNF1	AVPR2
Description		C1q and TNF related 1	arginine vasopressin receptor 2
Image		No pdb structure
GO Annotations	Cellular Component	Collagen Trimer Extracellular Space Integral Component Of Plasma Membrane	Endosome Endoplasmic Reticulum Golgi Apparatus Plasma Membrane Integral Component Of Plasma Membrane Integral Component Of Membrane Endocytic Vesicle Clathrin-coated Vesicle Membrane Perinuclear Region Of Cytoplasm
	Molecular Function	Protein Binding Collagen Binding Identical Protein Binding	G Protein-coupled Receptor Activity Vasopressin Receptor Activity Protein Binding Peptide Binding
	Biological Process	Positive Regulation Of Cytosolic Calcium Ion Concentration Negative Regulation Of Platelet Activation Positive Regulation Of Gene Expression Regulation Of Glucose Metabolic Process Positive Regulation Of MAPK Cascade Positive Regulation Of Protein Kinase B Signaling Negative Regulation Of Platelet Aggregation Positive Regulation Of Aldosterone Secretion	Regulation Of Systemic Arterial Blood Pressure By Vasopressin Renal Water Homeostasis G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Activation Of Adenylate Cyclase Activity Excretion Hemostasis Negative Regulation Of Cell Population Proliferation Positive Regulation Of Gene Expression Positive Regulation Of Vasoconstriction Membrane Organization
Pathways			Vasopressin-like receptors G alpha (s) signalling events Vasopressin regulates renal water homeostasis via Aquaporins Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis Defective AVP does not bind AVPR2 and causes neurohypophyseal diabetes insipidus (NDI) ADORA2B mediated anti-inflammatory cytokines production
Drugs			Desmopressin Vasopressin Demeclocycline Conivaptan Terlipressin M0002 OPC-51803 Tolvaptan Atosiban Lypressin
Diseases			Congenital nephrogenic diabetes insipidus (NDI)
GWAS
Interacting Genes		11 interacting genes: AVPR2 C14orf119 C1QTNF6 CACNA1A LMNA LNX1 PRPF31 SGTA TGM1 UBL5 UBQLN4	10 interacting genes: ARRB2 AVP C1QTNF1 COMT FXYD6-FXYD2 GNAS GNB1 GNG2 GRK5 SLC41A1
Entrez ID		114897	554
HPRD ID		12714	02368
Ensembl ID		ENSG00000173918	ENSG00000126895
Uniprot IDs		A0A0C4DFP7 A0A3B0J271 Q9BXJ1	P30518
PDB IDs			4JQI 6NI2 6U1N
Enriched GO Terms of Interacting Partners?
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