CHRNE and DUSP6

Data Source:
BioGRID (genetic interference)

		CHRNE	DUSP6
Description		cholinergic receptor nicotinic epsilon subunit	dual specificity phosphatase 6
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GO Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane Acetylcholine-gated Channel Complex Neuromuscular Junction Neuron Projection Synapse Postsynaptic Membrane	Nucleoplasm Cytoplasm Cytosol
	Molecular Function	Cation Transmembrane Transporter Activity Acetylcholine Receptor Activity Acetylcholine-gated Cation-selective Channel Activity Neurotransmitter Receptor Activity Transmitter-gated Ion Channel Activity Involved In Regulation Of Postsynaptic Membrane Potential	Phosphoprotein Phosphatase Activity Protein Tyrosine Phosphatase Activity Protein Binding Protein Tyrosine/threonine Phosphatase Activity MAP Kinase Tyrosine/serine/threonine Phosphatase Activity Mitogen-activated Protein Kinase Binding Protein Serine Phosphatase Activity Protein Threonine Phosphatase Activity
	Biological Process	Muscle Contraction Signal Transduction Chemical Synaptic Transmission Synaptic Transmission, Cholinergic Ion Transmembrane Transport Regulation Of Membrane Potential Nervous System Process Excitatory Postsynaptic Potential Cation Transmembrane Transport	MAPK Cascade Activation Of MAPK Activity Inactivation Of MAPK Activity Protein Dephosphorylation Response To Organic Cyclic Compound Cell Differentiation Peptidyl-tyrosine Dephosphorylation Peptidyl-threonine Dephosphorylation Response To Drug Positive Regulation Of Apoptotic Process Response To Nitrosative Stress Regulation Of Heart Growth Negative Regulation Of ERK1 And ERK2 Cascade Response To Growth Factor
Pathways		Highly sodium permeable postsynaptic acetylcholine nicotinic receptors	RAF-independent MAPK1/3 activation ERKs are inactivated Negative regulation of MAPK pathway Signaling by MAPK mutants
Drugs
Diseases		Congenital myasthenic syndrome
GWAS		Platelet count ( 29403010)	Attention deficit hyperactivity disorder ( 29325848 30478444) Night sleep phenotypes ( 27126917)
Interacting Genes		1 interacting genes: CHRNA1	12 interacting genes: AATK ERBB4 LMTK2 LTK MAPK1 MAPK3 MDFI ROR2 SRPK1 TEX11 TXK ZNF212
Entrez ID		1145	1848
HPRD ID		00008	04124
Ensembl ID		ENSG00000108556	ENSG00000139318
Uniprot IDs		Q04844	A0A024RBC1 Q16828 Q53GP9
PDB IDs		2DF9	1HZM 1MKP
Enriched GO Terms of Interacting Partners?
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