CHRNA7 and ADCY6

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vivo)

		CHRNA7	ADCY6
Description		cholinergic receptor nicotinic alpha 7 subunit	adenylate cyclase 6
Image			No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane Acetylcholine-gated Channel Complex Integral Component Of Membrane Neuron Projection Plasma Membrane Raft Synapse Postsynaptic Membrane Postsynapse	Plasma Membrane Integral Component Of Plasma Membrane Cilium Membrane Intrinsic Component Of Plasma Membrane Stereocilium
	Molecular Function	Amyloid-beta Binding Ion Channel Activity Calcium Channel Activity Protein Binding Acetylcholine Receptor Activity Toxic Substance Binding Chloride Channel Regulator Activity Acetylcholine-gated Cation-selective Channel Activity Neurotransmitter Receptor Activity Acetylcholine Binding Protein Homodimerization Activity	Adenylate Cyclase Activity Protein Kinase C Binding Protein Binding ATP Binding Protein Kinase Binding Metal Ion Binding
	Biological Process	Activation Of MAPK Activity Response To Hypoxia Positive Regulation Of Protein Phosphorylation Ion Transport Calcium Ion Transport Cellular Calcium Ion Homeostasis Signal Transduction Chemical Synaptic Transmission Synaptic Transmission, Cholinergic Learning Or Memory Memory Short-term Memory Positive Regulation Of Cell Population Proliferation Negative Regulation Of Tumor Necrosis Factor Production Ion Transmembrane Transport Response To Nicotine Regulation Of Membrane Potential Positive Regulation Of Angiogenesis Synapse Organization Nervous System Process Cognition Sensory Processing Positive Regulation Of Protein Metabolic Process Excitatory Postsynaptic Potential Positive Regulation Of ERK1 And ERK2 Cascade Calcium Ion Transmembrane Transport Acetylcholine Receptor Signaling Pathway Dendritic Spine Organization Modulation Of Excitatory Postsynaptic Potential Dendrite Arborization Positive Regulation Of Long-term Synaptic Potentiation Regulation Of Neuron Death Positive Regulation Of Amyloid-beta Formation Negative Regulation Of Amyloid-beta Formation Regulation Of Amyloid Precursor Protein Catabolic Process Response To Amyloid-beta Response To Acetylcholine Regulation Of Amyloid Fibril Formation Positive Regulation Of CoA-transferase Activity Positive Regulation Of Excitatory Postsynaptic Potential	Renal Water Homeostasis CAMP Biosynthetic Process G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Activation Of Adenylate Cyclase Activity Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Dopamine Receptor Signaling Pathway Negative Regulation Of Neuron Projection Development Activation Of Protein Kinase A Activity Negative Regulation Of Urine Volume Cellular Response To Glucagon Stimulus Cellular Response To Prostaglandin E Stimulus Cellular Response To Catecholamine Stimulus Blood Vessel Diameter Maintenance Cellular Response To Vasopressin Cellular Response To Forskolin
Pathways		Highly calcium permeable postsynaptic nicotinic acetylcholine receptors	Glucagon signaling in metabolic regulation PKA activation PKA activation in glucagon signalling Adenylate cyclase activating pathway Adenylate cyclase inhibitory pathway Adenylate cyclase inhibitory pathway Glucagon-like Peptide-1 (GLP1) regulates insulin secretion Adrenaline,noradrenaline inhibits insulin secretion G alpha (s) signalling events G alpha (s) signalling events G alpha (i) signalling events G alpha (z) signalling events G alpha (z) signalling events Vasopressin regulates renal water homeostasis via Aquaporins Hedgehog 'off' state ADORA2B mediated anti-inflammatory cytokines production ADORA2B mediated anti-inflammatory cytokines production FCGR3A-mediated IL10 synthesis
Drugs		Choline Nicotine Butabarbital Butalbital Talbutal Pentobarbital Methadone Secobarbital Metharbital Dextromethorphan Thiopental Mecamylamine Galantamine Primidone Methylphenobarbital Ethanol Amantadine Phenobarbital Tubocurarine Varenicline Amobarbital Aprobarbital Butobarbital Heptabarbital Hexobarbital Barbital Dihydro-2-thioxo-5-((5-(2-(trifluoromethyl)phenyl)-2-furanyl)methyl)-4,6(1H,5H)-pyrimidinedione Acetylcholine Lobeline GTS-21 RPI-78M Epibatidine Cytisine Cannabidiol Encenicline Choline salicylate Medical Cannabis Nabiximols
Diseases
GWAS		Hepatocyte growth factor levels ( 25998175)	Clozapine-induced agranulocytosis ( 25187353) Height ( 28552196)
Interacting Genes		4 interacting genes: ADCY6 APP ATXN1 PIK3R1	4 interacting genes: ATXN1 CHRNA7 GNAS RAF1
Entrez ID		1139	112
HPRD ID		00339	02621
Ensembl ID		ENSG00000175344	ENSG00000174233
Uniprot IDs		A0A0A6YYA8 P36544	O43306
PDB IDs		2MAW 5AFH 5AFJ 5AFK 5AFL 5AFM 5AFN
Enriched GO Terms of Interacting Partners?
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