LYPLA2 and DKC1

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		LYPLA2	DKC1
Description		lysophospholipase 2	dyskerin pseudouridine synthase 1
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Golgi Stack Cytosol Extracellular Exosome	Fibrillar Center Nucleus Nucleoplasm Telomerase Holoenzyme Complex Nucleolus Cytoplasm Box H/ACA SnoRNP Complex Box H/ACA ScaRNP Complex Box H/ACA Telomerase RNP Complex
	Molecular Function	Lysophospholipase Activity Protein Binding Palmitoyl-(protein) Hydrolase Activity Cadherin Binding Carboxylic Ester Hydrolase Activity	Telomerase Activity RNA Binding Protein Binding Pseudouridine Synthase Activity Box H/ACA SnoRNA Binding Telomerase RNA Binding
	Biological Process	Protein Depalmitoylation Fatty Acid Metabolic Process Axon Guidance Protein Phosphopantetheinylation Acylglycerol Catabolic Process Prostaglandin Catabolic Process	Enzyme-directed RRNA Pseudouridine Synthesis Box H/ACA RNA 3'-end Processing RRNA Processing RNA Processing Telomere Maintenance Via Telomerase RRNA Pseudouridine Synthesis SnRNA Pseudouridine Synthesis Positive Regulation Of Telomere Maintenance Via Telomerase Positive Regulation Of Telomerase Activity ScaRNA Localization To Cajal Body Telomerase RNA Stabilization Positive Regulation Of Establishment Of Protein Localization To Telomere Positive Regulation Of Protein Localization To Cajal Body Regulation Of Telomerase RNA Localization To Cajal Body Positive Regulation Of Telomerase RNA Localization To Cajal Body MRNA Pseudouridine Synthesis
Pathways		L1CAM interactions	Telomere Extension By Telomerase rRNA modification in the nucleus and cytosol
Drugs
Diseases			Hoyeraal-Hreidarsson syndrome Dyskeratosis congenita (DC), including: X-linked dyskeratosis congenita (DKCX); Autosomal dominant dyskeratosis congenita (DKCA1); Autosomal recessive dyskeratosis congenita (DKCB1)
GWAS
Interacting Genes		5 interacting genes: APP DKC1 INCA1 MED31 SCMH1	10 interacting genes: CSNK2A1 DAXX EEF1G EIF3F ERG LYPLA2 MAPK6 RUVBL1 SSR1 TERC
Entrez ID		11313	1736
HPRD ID		07127	02129
Ensembl ID		ENSG00000011009	ENSG00000130826
Uniprot IDs		A0A140VJC9 O95372	O60832
PDB IDs		5SYN 6BJE
Enriched GO Terms of Interacting Partners?
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