PADI2 and PADI4

Data Source:
HPRD (in vitro)

		PADI2	PADI4
Description		peptidyl arginine deiminase 2	peptidyl arginine deiminase 4
Image
GO Annotations	Cellular Component	Extracellular Region Nucleus Cytoplasm Cytosol Transcriptionally Active Chromatin Azurophil Granule Lumen Extracellular Exosome	Nucleus Nucleoplasm Cytoplasm Cytosol Protein-containing Complex
	Molecular Function	Protein-arginine Deiminase Activity Calcium Ion Binding Estrogen Receptor Binding Protein Homodimerization Activity	Protein-arginine Deiminase Activity Calcium Ion Binding Protein Binding Arginine Binding Identical Protein Binding
	Biological Process	Chromatin Organization Regulation Of Chromatin Disassembly Protein Citrullination Substantia Nigra Development Intracellular Estrogen Receptor Signaling Pathway Histone H3-R26 Citrullination Histone Citrullination Neutrophil Degranulation Chromatin-mediated Maintenance Of Transcription Negative Regulation Of Chemokine-mediated Signaling Pathway Negative Regulation Of Lymphocyte Chemotaxis Cellular Response To Leukemia Inhibitory Factor	Chromatin Organization Nucleosome Assembly Chromatin Remodeling Cellular Protein Modification Process Protein Citrullination Stem Cell Population Maintenance Histone H3-R26 Citrullination Histone Citrullination Innate Immune Response
Pathways		Chromatin modifying enzymes Neutrophil degranulation	Chromatin modifying enzymes
Drugs		Citrulline	Citrulline Azithromycin Tetracycline Streptomycin N-[(1S)-1-(aminocarbonyl)-4-(ethanimidoylamino)butyl]benzamide
Diseases
GWAS		Gut microbiota relative abundance (Ruminococcus belonging to family Lachnospiraceae) ( 33208821) Hemoglobin ( 32888494) Prudent dietary pattern ( 28644415) Rheumatoid arthritis ( 30423114) Visceral fat ( 30942860)	Autoimmune traits (pleiotropy) ( 30572963) Basal cell carcinoma ( 18849993) Basophil count ( 32888494) Basophil percentage of white cells ( 32888494) IgA nephropathy ( 25305756) Rheumatoid arthritis ( 21452313 21505073 30423114 30572963 23143596 24390342) Rheumatoid arthritis (ACPA-positive) ( 23143596 24532676)
Interacting Genes			10 interacting genes: ANXA4 APP FBXO25 H3C15 HDAC2 LRRK2 NPM1 POU6F2 SMURF1 TRIB3
Entrez ID		11240	23569
HPRD ID		06396	05635
Ensembl ID		ENSG00000117115	ENSG00000159339
Uniprot IDs		Q9Y2J8	Q9UM07
PDB IDs		4N20 4N22 4N24 4N25 4N26 4N28 4N2A 4N2B 4N2C 4N2D 4N2E 4N2F 4N2G 4N2H 4N2I 4N2K 4N2L 4N2M 4N2N	1WD8 1WD9 1WDA 2DEW 2DEX 2DEY 2DW5 3APM 3APN 3B1T 3B1U 4DKT 4X8C 4X8G 5N0M 5N0Y 5N0Z 5N1B
Enriched GO Terms of Interacting Partners?
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