CHN2 and ITGB8

Data Source:
BioGRID (genetic interference)

		CHN2	ITGB8
Description		chimerin 2	integrin subunit beta 8
Image
GO Annotations	Cellular Component	Cytosol Membrane Synapse	Plasma Membrane Focal Adhesion Integrin Complex Cell Surface Integrin Alphav-beta8 Complex Extracellular Exosome
	Molecular Function	GTPase Activator Activity Protein Binding Metal Ion Binding	Integrin Binding Signaling Receptor Activity Extracellular Matrix Protein Binding
	Biological Process	Intracellular Signal Transduction Regulation Of GTPase Activity Positive Regulation Of GTPase Activity Regulation Of Small GTPase Mediated Signal Transduction	Vasculogenesis Ganglioside Metabolic Process Immune Response Cell Adhesion Cell-matrix Adhesion Transforming Growth Factor Beta Receptor Signaling Pathway Integrin-mediated Signaling Pathway Response To Virus Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Cell Migration Extracellular Matrix Organization Cell Adhesion Mediated By Integrin Positive Regulation Of Angiogenesis Cartilage Development Hard Palate Development Placenta Blood Vessel Development Langerhans Cell Differentiation Regulation Of Transforming Growth Factor Beta Activation
Pathways		Rho GTPase cycle	Molecules associated with elastic fibres Integrin cell surface interactions
Drugs
Diseases
GWAS		Circulating leptin levels in high cardiovascular risk ( 31766143) CSF tryptophan concentration in tuberculous meningitis ( 29395996) Erosive tooth wear (severe vs non-severe) ( 29898447) Erosive tooth wear (severe vs none or mild) ( 29898447) Facial emotion recognition ( 28608620) Facial emotion recognition (angry faces) ( 28608620) Facial emotion recognition (sad faces) ( 28608620) Gut microbiota alpha diversity (PD_whole_tree index) ( 33208821) Itch intensity from mosquito bite adjusted by bite size ( 28199695) Loneliness (linear analysis) ( 27629369) Methadone dose in opioid dependence ( 28115739) Obesity-related traits ( 23251661) Psychosis (atypical) ( 24132900) Triglyceride levels ( 32203549) Waist circumference adjusted for body mass index ( 28552196)	Allergic disease (asthma, hay fever or eczema) ( 29083406) Allergic rhinitis ( 31361310) Asthma ( 31361310 31959851 30929738 31619474) Asthma (childhood onset) ( 30929738) Asthma onset (childhood vs adult) ( 30929738) Asthma or allergic disease (pleiotropy) ( 29785011) Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Chronic obstructive pulmonary disease ( 30804561) Eosinophil counts ( 29403010 32888494) Eosinophil percentage of white cells ( 32888494) Inflammatory bowel disease ( 28067908) Medication use (adrenergics, inhalants) ( 31015401) Metabolite levels ( 23823483) Non-lobar intracerebral hemorrhage (MTAG) ( 31430377) Prostate cancer ( 29892016) Waist circumference adjusted for BMI (adjusted for smoking behaviour) ( 28443625) Waist circumference adjusted for BMI (joint analysis main effects and physical activity interaction) ( 28448500) Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction) ( 28443625) Waist circumference adjusted for BMI in active individuals ( 28448500) Waist circumference adjusted for BMI in non-smokers ( 28443625) Waist circumference adjusted for body mass index ( 25673412 28448500)
Interacting Genes		14 interacting genes: ANKK1 BAG6 ERBB3 NCK1 NCK2 RAC1 RACGAP1 RANBP3 RB1 SENP8 SHF SMARCD1 TGFBR1 TP53RK	3 interacting genes: ITGAV TGFB1 VTN
Entrez ID		1124	3696
HPRD ID		04173	05001
Ensembl ID		ENSG00000106069	ENSG00000105855
Uniprot IDs		A0A2X0TVW3 B3VCF4 B3VCF5 B3VCF6 B3VCF9 B7Z1V0 B7Z1W9 B7Z215 B7Z232 P52757	P26012 Q9BUG9
PDB IDs		1XA6	6DJP 6OM1 6OM2 6UJA 6UJB 6UJC
Enriched GO Terms of Interacting Partners?
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