TREX2 and POLD1

Data Source:
HPRD (in vitro)

		TREX2	POLD1
Description		three prime repair exonuclease 2	DNA polymerase delta 1, catalytic subunit
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GO Annotations	Cellular Component	Nucleus Cytoplasm	Nucleotide-excision Repair Complex Chromosome, Telomeric Region Nucleus Nucleoplasm Cytosol Membrane Aggresome Delta DNA Polymerase Complex
	Molecular Function	Magnesium Ion Binding Nucleic Acid Binding Protein Binding 3'-5'-exodeoxyribonuclease Activity Exodeoxyribonuclease III Activity Protein Homodimerization Activity	Nucleotide Binding DNA Binding Chromatin Binding Damaged DNA Binding DNA-directed DNA Polymerase Activity Protein Binding 3'-5'-exodeoxyribonuclease Activity Metal Ion Binding 4 Iron, 4 Sulfur Cluster Binding
	Biological Process	DNA Catabolic Process, Exonucleolytic DNA Metabolic Process DNA Repair	Telomere Maintenance DNA Synthesis Involved In DNA Repair DNA Replication DNA-dependent DNA Replication DNA Repair Transcription-coupled Nucleotide-excision Repair Base-excision Repair, Gap-filling Nucleotide-excision Repair, DNA Incision, 5'-to Lesion Nucleotide-excision Repair, DNA Gap Filling Mismatch Repair Response To UV Translesion Synthesis Telomere Maintenance Via Semi-conservative Replication Nucleotide-excision Repair, DNA Incision Cellular Response To UV DNA Damage Response, Detection Of DNA Damage DNA Replication Proofreading Fatty Acid Homeostasis Error-free Translesion Synthesis DNA Biosynthetic Process
Pathways			Recognition of DNA damage by PCNA-containing replication complex Polymerase switching on the C-strand of the telomere Processive synthesis on the C-strand of the telomere Telomere C-strand (Lagging Strand) Synthesis Removal of the Flap Intermediate from the C-strand Cytosolic iron-sulfur cluster assembly Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) PCNA-Dependent Long Patch Base Excision Repair Termination of translesion DNA synthesis HDR through Homologous Recombination (HRR) Gap-filling DNA repair synthesis and ligation in GG-NER Dual Incision in GG-NER Dual incision in TC-NER Gap-filling DNA repair synthesis and ligation in TC-NER Polymerase switching Removal of the Flap Intermediate Processive synthesis on the lagging strand
Drugs
Diseases
GWAS			Dental caries (decayed, missing and filled tooth surfaces) ( 31533690) Obesity-related traits ( 23251661)
Interacting Genes		3 interacting genes: ATF4 MESD POLD1	22 interacting genes: ADAMTSL4 ATR CCND3 CCNE1 CDK2 CDK4 CEP126 CHGB GINS4 LASP1 MCPH1 PCNA POLD2 POLD3 POLD4 SUMO2 TERF2IP TREX2 TRIM55 WRNIP1 XRCC5 YPEL3
Entrez ID		11219	5424
HPRD ID		02299	08882
Ensembl ID		ENSG00000183479	ENSG00000062822
Uniprot IDs		Q9BQ50	A0A024R4F4 A0A087WYJ2 M0R2B7 P28340 Q308M6 Q59FA0
PDB IDs		1Y97	6S1M 6S1N 6S1O 6TNY 6TNZ
Enriched GO Terms of Interacting Partners?
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