ADAMTS6 and CD180

Data Source:
BioGRID (proximity labelling technology)

		ADAMTS6	CD180
Description		ADAM metallopeptidase with thrombospondin type 1 motif 6	CD180 molecule
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Matrix	Extracellular Space Plasma Membrane Integral Component Of Membrane Extracellular Matrix
	Molecular Function	Metalloendopeptidase Activity Metallopeptidase Activity Metal Ion Binding	Protein Binding
	Biological Process	Kidney Development Cardiac Septum Development Proteolysis Extracellular Matrix Organization Aorta Development Coronary Vasculature Development	B Cell Proliferation Involved In Immune Response Inflammatory Response Positive Regulation Of Lipopolysaccharide-mediated Signaling Pathway Innate Immune Response Cellular Response To Lipopolysaccharide
Pathways		Defective B3GALTL causes Peters-plus syndrome (PpS) O-glycosylation of TSR domain-containing proteins	Toll Like Receptor 4 (TLR4) Cascade
Drugs
Diseases
GWAS		Brain morphology (MOSTest) ( 32665545) Central corneal thickness ( 32528159 31798171 29760442) Corneal structure ( 23291589) Corpus callosum anterior volume ( 31530798) Cortical surface area (MOSTest) ( 32665545) Feeling tense ( 29500382) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223) Heel bone mineral density ( 30598549) Height ( 31562340) Inguinal hernia ( 26686553) Intraocular pressure ( 29617998 29785010 30054594) Non-response to bupropion and depression ( 27622933) Osteosarcoma ( 23727862) Schizophrenia ( 23212062) Subcortical volume (MOSTest) ( 32665545)	Common carotid intima-media thickness in HIV infection ( 29206233) General cognitive ability ( 29844566) Gut microbiota (bacterial taxa) ( 27723756)
Interacting Genes		1 interacting genes: SNTA1	1 interacting genes: LY86
Entrez ID		11174	4064
HPRD ID		05421	03749
Ensembl ID		ENSG00000049192	ENSG00000134061
Uniprot IDs		Q5IR90 Q9UKP5	Q99467
PDB IDs			3B2D
Enriched GO Terms of Interacting Partners?
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