ADAMTS6 and ERCC8

Data Source:
BioGRID (affinity chromatography technology)

		ADAMTS6	ERCC8
Description		ADAM metallopeptidase with thrombospondin type 1 motif 6	ERCC excision repair 8, CSA ubiquitin ligase complex subunit
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Matrix	Nucleotide-excision Repair Complex Nucleus Nucleoplasm Cytoplasm Nuclear Matrix Cul4A-RING E3 Ubiquitin Ligase Complex Protein-containing Complex Perikaryon Cul4-RING E3 Ubiquitin Ligase Complex
	Molecular Function	Metalloendopeptidase Activity Metallopeptidase Activity Metal Ion Binding	DNA Helicase Activity Ubiquitin-protein Transferase Activity Protein Binding DNA-dependent ATPase Activity Protein-containing Complex Binding
	Biological Process	Kidney Development Cardiac Septum Development Proteolysis Extracellular Matrix Organization Aorta Development Coronary Vasculature Development	Single Strand Break Repair Protein Polyubiquitination Transcription-coupled Nucleotide-excision Repair Nucleotide-excision Repair Cellular Response To DNA Damage Stimulus Response To Oxidative Stress Response To UV Response To X-ray Response To Auditory Stimulus Response To Organic Cyclic Compound DNA Duplex Unwinding Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Post-translational Protein Modification Positive Regulation Of DNA Repair Protein Autoubiquitination Double-strand Break Repair Via Classical Nonhomologous End Joining
Pathways		Defective B3GALTL causes Peters-plus syndrome (PpS) O-glycosylation of TSR domain-containing proteins	Formation of TC-NER Pre-Incision Complex Transcription-Coupled Nucleotide Excision Repair (TC-NER) Dual incision in TC-NER Gap-filling DNA repair synthesis and ligation in TC-NER Neddylation
Drugs
Diseases			Disorders of nucleotide excision repair, including: Xeroderma pigmentosum (XP); Cockayne syndrome (CS); UV-sensitive syndrome (UVS); Trichothiodystrophy (TTD); Cerebro-oculo-facio-skeletal syndrome (COFS); XFE progeroid syndrome Cockayne syndrome
GWAS		Brain morphology (MOSTest) ( 32665545) Central corneal thickness ( 32528159 31798171 29760442) Corneal structure ( 23291589) Corpus callosum anterior volume ( 31530798) Cortical surface area (MOSTest) ( 32665545) Feeling tense ( 29500382) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223) Heel bone mineral density ( 30598549) Height ( 31562340) Inguinal hernia ( 26686553) Intraocular pressure ( 29617998 29785010 30054594) Non-response to bupropion and depression ( 27622933) Osteosarcoma ( 23727862) Schizophrenia ( 23212062) Subcortical volume (MOSTest) ( 32665545)	Autism spectrum disorder or schizophrenia ( 28540026) Brain morphology (MOSTest) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Subcortical volume (MOSTest) ( 32665545)
Interacting Genes		1 interacting genes: SNTA1	11 interacting genes: CAMK2D CBR1 CSNK2B CUL4A DDB1 ERCC6 GTF2H2 RBX1 TOP1 UQCRQ XAB2
Entrez ID		11174	1161
HPRD ID		05421	07523
Ensembl ID		ENSG00000049192	ENSG00000049167
Uniprot IDs		Q5IR90 Q9UKP5	A0A0S2Z3L1 B3KPW7 B4DGZ9 Q13216
PDB IDs			4A11 6FCV
Enriched GO Terms of Interacting Partners?
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