AP4S1 and GTF2I

Data Source:
BioGRID (two hybrid)

		AP4S1	GTF2I
Description		adaptor related protein complex 4 subunit sigma 1	general transcription factor IIi
Image		No pdb structure
GO Annotations	Cellular Component	AP-4 Adaptor Complex Endosome Lumen Trans-Golgi Network Membrane Intracellular Membrane-bounded Organelle	Nucleus Nucleoplasm Cytoplasm Membrane
	Molecular Function		DNA-binding Transcription Factor Activity, RNA Polymerase II-specific RNA Polymerase II Activating Transcription Factor Binding DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding
	Biological Process	Protein Targeting Protein Localization Vesicle-mediated Transport	Negative Regulation Of Angiogenesis Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of DNA Repair By Transcription From RNA Polymerase II Promoter
Pathways		Lysosome Vesicle Biogenesis
Drugs
Diseases		Cerebral palsy
GWAS		Brain morphology (MOSTest) ( 32665545) Mean corpuscular volume ( 32888494)	Atrial fibrillation ( 30061737 29892015) C-reactive protein levels ( 30388399) Chronic obstructive pulmonary disease or high blood pressure (pleiotropy) ( 30940143) Diastolic blood pressure ( 30224653) HDL cholesterol levels ( 32203549) Heel bone mineral density ( 30598549) Menarche (age at onset) ( 25231870) SjÃ¶gren's syndrome ( 24097066 27503288) Systemic lupus erythematosus ( 28714469)
Interacting Genes		6 interacting genes: AFP APP GRB2 GTF2I HTR6 TEAD3	46 interacting genes: AP1B1 AP2B1 AP4S1 ATF6 BCL2L11 BTK C4BPA CALM1 CTAG1A CTAG1B DNMT3L DPY30 ERCC6 GCC1 HDAC3 JAK2 LINC01554 LSM8 MAP3K3 MAPK12 MAPK3 MTUS2 MYC NFKB2 PIAS2 PJA1 POU2AF1 PRKG1 PRRX1 SLU7 SMAD2 SNRPN SRC SRF STAT1 STAT3 SUMO2 TAB2 TRAF6 TRIM54 UBC UBE2I USF1 YY1 ZBTB17 ZMYM3
Entrez ID		11154	2969
HPRD ID		06257	03399
Ensembl ID		ENSG00000100478	ENSG00000263001
Uniprot IDs		Q9Y587	A8K9W7 P78347 Q499G6 X5D2J9 X5D939 X5DNP5 X5DR09
PDB IDs			2D9B 2DN4 2ED2 2EJE
Enriched GO Terms of Interacting Partners?
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