CIT and ENPP7

Data Source:
HPRD (in vitro, in vivo)

		CIT	ENPP7
Description		citron rho-interacting serine/threonine kinase	ectonucleotide pyrophosphatase/phosphodiesterase 7
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol Cytoskeleton Membrane	Golgi Apparatus Plasma Membrane Integral Component Of Plasma Membrane Microvillus Membrane
	Molecular Function	Transcription Coactivator Binding Protein Serine/threonine Kinase Activity Protein Binding ATP Binding SH3 Domain Binding Protein Kinase Binding PDZ Domain Binding Protein Serine/threonine Kinase Inhibitor Activity Metal Ion Binding Scaffold Protein Binding Protein Serine Kinase Activity Protein Threonine Kinase Activity	Sphingomyelin Phosphodiesterase Activity Protein Binding Phosphoric Diester Hydrolase Activity Zinc Ion Binding
	Biological Process	Mitotic Cell Cycle Mitotic Cytokinesis Peptidyl-threonine Phosphorylation Actomyosin Structure Organization Positive Regulation Of Cytokinesis Negative Regulation Of Hippo Signaling Intracellular Signal Transduction Generation Of Neurons Neuron Apoptotic Process Negative Regulation Of Protein Serine/threonine Kinase Activity	Sphingomyelin Metabolic Process Sphingomyelin Catabolic Process Glycosphingolipid Metabolic Process Negative Regulation Of DNA Replication Negative Regulation Of Cell Population Proliferation Lipid Digestion Positive Regulation Of Intestinal Cholesterol Absorption Fatty Acid Homeostasis Regulation Of Intestinal Lipid Absorption Positive Regulation Of Ceramide Biosynthetic Process Positive Regulation Of Sphingomyelin Catabolic Process
Pathways		RHO GTPases activate CIT RHO GTPases activate CIT	Glycosphingolipid metabolism
Drugs		Fostamatinib
Diseases
GWAS		Number of sexual partners ( 30643258) Urgency urinary incontinence ( 25524241)	Blood protein levels ( 30072576 29875488) Diastolic blood pressure response to hydrochlorothiazide in hypertension ( 27802415)
Interacting Genes		10 interacting genes: DISC1 DLG4 GRIN1 GRIN2D MTNR1A RAC1 RHOA RHOB RHOC RND3	5 interacting genes: BACH2 GOLGA2 KRTAP5-9 LRRC73 MTUS2
Entrez ID		11113	339221
HPRD ID		09289	10938
Ensembl ID		ENSG00000122966	ENSG00000182156
Uniprot IDs		O14578	Q6UWV6
PDB IDs			5TCD 5UDY
Enriched GO Terms of Interacting Partners?
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