ADAMTS5 and MMP13

Data Source:
HPRD (in vitro)

		ADAMTS5	MMP13
Description		ADAM metallopeptidase with thrombospondin type 1 motif 5	matrix metallopeptidase 13
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GO Annotations	Cellular Component	Extracellular Region Extracellular Space Endoplasmic Reticulum Lumen Extracellular Matrix Collagen-containing Extracellular Matrix	Extracellular Region Extracellular Space Extracellular Matrix
	Molecular Function	Metalloendopeptidase Activity Integrin Binding Protein Binding Heparin Binding Peptidase Activity Metallopeptidase Activity Zinc Ion Binding Extracellular Matrix Binding	Endopeptidase Activity Metalloendopeptidase Activity Calcium Ion Binding Collagen Binding Zinc Ion Binding
	Biological Process	Proteolysis Extracellular Matrix Disassembly Extracellular Matrix Organization Defense Response To Bacterium Tooth Eruption Negative Regulation Of Cold-induced Thermogenesis	Proteolysis Extracellular Matrix Disassembly Extracellular Matrix Organization Collagen Catabolic Process Bone Morphogenesis Response To Amyloid-beta
Pathways		Degradation of the extracellular matrix Degradation of the extracellular matrix Defective B3GALTL causes Peters-plus syndrome (PpS) O-glycosylation of TSR domain-containing proteins	Collagen degradation Collagen degradation Degradation of the extracellular matrix Degradation of the extracellular matrix Activation of Matrix Metalloproteinases Assembly of collagen fibrils and other multimeric structures RUNX2 regulates genes involved in cell migration
Drugs		Batimastat (2R)-N~4~-hydroxy-2-(3-hydroxybenzyl)-N~1~-[(1S,2R)-2-hydroxy-2,3-dihydro-1H-inden-1-yl]butanediamide N-hydroxy-4-({4-[4-(trifluoromethyl)phenoxy]phenyl}sulfonyl)tetrahydro-2H-pyran-4-carboxamide	Marimastat 3-Methylpyridine 2-{4-[4-(4-Chloro-Phenoxy)-Benzenesulfonyl]-Tetrahydro-Pyran-4-Yl}-N-Hydroxy-Acetamide WAY-151693 Hydroxyaminovaline 4-methoxybenzenesulfinate PYRIMIDINE-4,6-DICARBOXYLIC ACID BIS-(3-METHYL-BENZYLAMIDE) PYRIMIDINE-4,6-DICARBOXYLIC ACID BIS-(4-FLUORO-3-METHYL-BENZYLAMIDE) PYRIMIDINE-4,6-DICARBOXYLIC ACID BIS-[(PYRIDIN-3-YLMETHYL)-AMIDE] Endostatin TERT-BUTYL 4-({[4-(BUT-2-YN-1-YLAMINO)PHENYL]SULFONYL}METHYL)-4-[(HYDROXYAMINO)CARBONYL]PIPERIDINE-1-CARBOXYLATE 4-{[1-METHYL-2,4-DIOXO-6-(3-PHENYLPROP-1-YN-1-YL)-1,4-DIHYDROQUINAZOLIN-3(2H)-YL]METHYL}BENZOIC ACID 5-(2-ETHOXYETHYL)-5-[4-(4-FLUOROPHENOXY)PHENOXY]PYRIMIDINE-2,4,6(1H,3H,5H)-TRIONE CTS-1027 BENZYL 6-BENZYL-5,7-DIOXO-6,7-DIHYDRO-5H-[1,3]THIAZOLO[3,2-C]PYRIMIDINE-2-CARBOXYLATE
Diseases			Metaphyseal dysplasias, including: Metaphyseal dysplasia, Schmid type; Metaphyseal dysplasia, McKusik type; Metaphyseal dysplasia, Jansen type; Shwachman-Bodian-Diamond syndrome (SBDS); Metaphyseal anadysplasia (MAD)
GWAS		Blood protein levels ( 30072576 29875488 28240269) Dialysis-related mortality ( 21546767) Diastolic blood pressure ( 29343252) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Height ( 31562340) Plasma anti-thyroglobulin and anti-thyroid peroxidase levels (bivariate analysis) ( 29678681)	Cerebrospinal fluid levels of Alzheimer's disease-related proteins ( 25340798) Diisocyanate-induced asthma ( 25918132) Peanut allergy ( 29030101)
Interacting Genes		2 interacting genes: ACAN MMP13	9 interacting genes: ADAMTS5 BCAN CCL7 COL2A1 F12 FBXO7 LRP1 MMP14 TIMP3
Entrez ID		11096	4322
HPRD ID		05420	02522
Ensembl ID		ENSG00000154736	ENSG00000137745
Uniprot IDs		Q9UNA0	P45452 Q53H33
PDB IDs		2RJQ 3B8Z 3HY7 3HY9 3HYG 3LJT	1EUB 1FLS 1FM1 1PEX 1UC1 1XUC 1XUD 1XUR 1YOU 1ZTQ 2D1N 2E2D 2OW9 2OZR 2PJT 2YIG 3ELM 3I7G 3I7I 3KEC 3KEJ 3KEK 3KRY 3LJZ 3O2X 3TVC 3WV1 3WV2 3WV3 3ZXH 456C 4A7B 4FU4 4FVL 4G0D 4JP4 4JPA 4L19 5B5O 5B5P 5BOT 5BOY 5BPA 5UWK 5UWL 5UWM 5UWN 830C
Enriched GO Terms of Interacting Partners?
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