ADAMTS8 and IGSF9B

Data Source:
HPRD (in vitro)

		ADAMTS8	IGSF9B
Description		ADAM metallopeptidase with thrombospondin type 1 motif 8	immunoglobulin superfamily member 9B
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Extracellular Matrix Collagen-containing Extracellular Matrix	Postsynaptic Density Integral Component Of Membrane Neuron Projection Postsynaptic Membrane GABA-ergic Synapse Postsynaptic Specialization Of Symmetric Synapse
	Molecular Function	Metalloendopeptidase Activity Integrin Binding Heparin Binding Metallopeptidase Activity Zinc Ion Binding Low-affinity Phosphate Transmembrane Transporter Activity
	Biological Process	Proteolysis Negative Regulation Of Cell Population Proliferation Extracellular Matrix Organization Phosphate Ion Transmembrane Transport	Cell Adhesion Nervous System Development
Pathways		Degradation of the extracellular matrix Defective B3GALTL causes Peters-plus syndrome (PpS) O-glycosylation of TSR domain-containing proteins
Drugs
Diseases
GWAS		Brain morphology (MOSTest) ( 32665545) Central corneal thickness ( 32528159 31798171 29760442) Corneal astigmatism ( 30306274) Corneal hysteresis ( 31246245) Corneal resistance factor ( 31246245) Diastolic blood pressure ( 27841878) Intraocular pressure ( 29617998 28073927 29235454) Metabolite levels ( 23823483) Optic cup area ( 28073927) Pulse pressure ( 26390057 28135244 27841878 28739976) Pulse pressure x alcohol consumption interaction (2df test) ( 29912962) Systolic blood pressure ( 27841878) Vertical cup-disc ratio ( 31798171 25241763 28073927) Vertical cup-disc ratio (adjusted for vertical disc diameter) ( 31959993) Vertical cup-disc ratio (multi-trait analysis) ( 31959993)	Adult body size ( 32376654) Alcohol consumption ( 31358974) anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028) Autism spectrum disorder or schizophrenia ( 28540026) Bitter alcoholic beverage consumption ( 31046077) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) Emphysema annual change measurement in smokers (adjusted lung density) ( 31324189) Feeling worry ( 29500382) Hand grip strength ( 29313844) Longitudinal alcohol consumption ( 26081443) Migraine ( 27322543) Neurociticism ( 29500382) Obesity-related traits ( 23251661) Parkinson's disease ( 32201043) Parkinson's disease or first degree relation to individual with Parkinson's disease ( 31701892) Schizophrenia ( 28991256 25056061 29483656 30285260)
Interacting Genes
Entrez ID		11095	22997
HPRD ID		05531	13828
Ensembl ID		ENSG00000134917	ENSG00000080854
Uniprot IDs		Q5FWF1 Q9UP79	Q8N7W7 Q9UPX0
PDB IDs
Enriched GO Terms of Interacting Partners?
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