ADAMTS8

Description		ADAM metallopeptidase with thrombospondin type 1 motif 8
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Matrix Collagen-containing Extracellular Matrix
	Molecular Function	Metalloendopeptidase Activity Integrin Binding Heparin Binding Metallopeptidase Activity Zinc Ion Binding Low-affinity Phosphate Transmembrane Transporter Activity
	Biological Process	Proteolysis Negative Regulation Of Cell Population Proliferation Extracellular Matrix Organization Phosphate Ion Transmembrane Transport
Pathways		Degradation of the extracellular matrix Defective B3GALTL causes Peters-plus syndrome (PpS) O-glycosylation of TSR domain-containing proteins
Drugs
Diseases
GWAS		Brain morphology (MOSTest) ( 32665545) Central corneal thickness ( 32528159 31798171 29760442) Corneal astigmatism ( 30306274) Corneal hysteresis ( 31246245) Corneal resistance factor ( 31246245) Diastolic blood pressure ( 27841878) Intraocular pressure ( 29617998 28073927 29235454) Metabolite levels ( 23823483) Optic cup area ( 28073927) Pulse pressure ( 26390057 28135244 27841878 28739976) Pulse pressure x alcohol consumption interaction (2df test) ( 29912962) Systolic blood pressure ( 27841878) Vertical cup-disc ratio ( 31798171 25241763 28073927) Vertical cup-disc ratio (adjusted for vertical disc diameter) ( 31959993) Vertical cup-disc ratio (multi-trait analysis) ( 31959993)
Novel Interacting Genes		1 novel interacting genes: IGSF9B
Interacting Genes
Entrez ID		11095
HPRD ID		05531
Ensembl ID		ENSG00000134917
Uniprot IDs		Q5FWF1 Q9UP79
PDB IDs
Enriched GO Terms of Interacting Partners?
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