SLC27A4 and MARK3

Data Source:
BioGRID (proximity labelling technology)

		SLC27A4	MARK3
Description		solute carrier family 27 member 4	microtubule affinity regulating kinase 3
Image		No pdb structure
GO Annotations	Cellular Component	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Plasma Membrane Microvillus Membrane Integral Component Of Membrane Brush Border Membrane	Cytoplasm Cytosol Plasma Membrane Dendrite Extracellular Exosome
	Molecular Function	Nucleotide Binding Long-chain Fatty Acid-CoA Ligase Activity Long-chain Fatty Acid Transporter Activity Very Long-chain Fatty Acid-CoA Ligase Activity Arachidonate-CoA Ligase Activity Palmitoyl-CoA Ligase Activity Oleoyl-CoA Ligase Activity	Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Tau Protein Binding Tau-protein Kinase Activity Protein Serine Kinase Activity Protein Threonine Kinase Activity
	Biological Process	Medium-chain Fatty Acid Transport Long-chain Fatty Acid Metabolic Process Fatty Acid Metabolic Process Response To Nutrient Fatty Acid Transport Long-chain Fatty Acid Transport Very Long-chain Fatty Acid Catabolic Process Positive Regulation Of Apoptotic Process Skin Development Glucose Import In Response To Insulin Stimulus Long-chain Fatty Acid Import Into Cell Negative Regulation Of Insulin Receptor Signaling Pathway Negative Regulation Of All-trans-retinyl-ester Hydrolase, 11-cis Retinol Forming Activity Activation Of GTPase Activity Transport Across Blood-brain Barrier Lipid Transport Across Blood-brain Barrier	MAPK Cascade Microtubule Cytoskeleton Organization Protein Phosphorylation Peptidyl-serine Phosphorylation Positive Regulation Of Protein Binding Negative Regulation Of Hippo Signaling Intracellular Signal Transduction Peptidyl-serine Autophosphorylation
Pathways		Defective SLC27A4 causes ichthyosis prematurity syndrome (IPS) Transport of fatty acids	RAF activation MAP2K and MAPK activation Negative regulation of MAPK pathway Signaling by moderate kinase activity BRAF mutants Signaling by high-kinase activity BRAF mutants Signaling by BRAF and RAF fusions Paradoxical activation of RAF signaling by kinase inactive BRAF Signaling downstream of RAS mutants Signaling by RAF1 mutants
Drugs			Fostamatinib
Diseases		Ichthyosis prematurity syndrome
GWAS		Body mass index ( 26426971)	Autism spectrum disorder or schizophrenia ( 28540026) Blond vs. brown/black hair color ( 30531825) Body mass index ( 26426971) Brain morphology (MOSTest) ( 32665545) Coronary artery disease ( 29212778 33020668) Cutaneous melanoma or hair colour ( 32341527) Femoral neck bone mineral density ( 22504420) Granulocyte percentage of myeloid white cells ( 27863252) Heel bone mineral density ( 30598549 28869591) Height ( 31562340) Lymphocyte counts ( 32888494) Mean corpuscular hemoglobin ( 32888494 27863252) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Monocyte count ( 29403010 32888494 27863252) Monocyte percentage of white cells ( 32888494) Neutrophil percentage of white cells ( 32888494) Optic disc size ( 31809533) PR interval ( 32439900) Systolic blood pressure ( 30224653 30578418) Type 2 diabetes ( 30297969) White blood cell count ( 32888494)
Interacting Genes		2 interacting genes: EPS8 TENT5B	30 interacting genes: ANKRD7 ARHGEF2 ASB13 ATP6V0C CDC25C CHGB CLASP1 CLASP2 CPSF4 DYNLL1 FANCF FBXO7 HDAC7 KSR1 MAP2 MAPT MITF NOL11 PKP2 PMPCB PNPLA2 PRKCQ SAAL1 SFN TCEA2 TTR VPS11 YWHAG YWHAQ YWHAZ
Entrez ID		10999	4140
HPRD ID		09172	04058
Ensembl ID		ENSG00000167114	ENSG00000075413
Uniprot IDs		A0A024R8D2 Q6P1M0	P27448 Q86U11
PDB IDs			2QNJ 3FE3
Enriched GO Terms of Interacting Partners?
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