SDS and IFT81

Data Source:
BioGRID (biochemical)

		SDS	IFT81
Description		serine dehydratase	intraflagellar transport 81
Image			No pdb structure
GO Annotations	Cellular Component	Mitochondrion Cytosol	Centrosome Cilium Intraciliary Transport Particle B Motile Cilium Ciliary Basal Body Ciliary Tip
	Molecular Function	L-serine Ammonia-lyase Activity L-threonine Ammonia-lyase Activity Protein Binding Pyridoxal Phosphate Binding Protein Homodimerization Activity	Protein Binding Tubulin Binding
	Biological Process	Gluconeogenesis L-serine Catabolic Process Threonine Catabolic Process Isoleucine Biosynthetic Process L-threonine Catabolic Process To Glycine Pyruvate Biosynthetic Process	Spermatogenesis Regulation Of Smoothened Signaling Pathway Intraciliary Transport Involved In Cilium Assembly Intraciliary Transport Cilium Assembly
Pathways		Threonine catabolism	Intraflagellar transport Intraflagellar transport
Drugs		Pyridoxal phosphate Serine
Diseases
GWAS		Body mass index ( 26426971) Low high density lipoprotein cholesterol levels ( 26879886)	anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028) Bipolar disorder ( 31043756) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Headache ( 29397368) Intelligence (MTAG) ( 29326435) Total intracranial volume ( 31530798)
Interacting Genes		3 interacting genes: DDI1 HGS TGM7	2 interacting genes: APP IFT74
Entrez ID		10993	28981
HPRD ID		01633	09266
Ensembl ID		ENSG00000135094	ENSG00000122970
Uniprot IDs		P20132 Q8WW81	A0A024RBJ1 Q8WYA0
PDB IDs		1P5J 4H27
Enriched GO Terms of Interacting Partners?
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