ASCC3 and TRIP4

Data Source:
HPRD (in vivo, two hybrid)

		ASCC3	TRIP4
Description		activating signal cointegrator 1 complex subunit 3	thyroid hormone receptor interactor 4
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytosol Membrane Nuclear Speck Activating Signal Cointegrator 1 Complex	Nucleus Nucleoplasm Cytoplasm Centrosome Cytosol Nuclear Body Neuromuscular Junction Protein-containing Complex Activating Signal Cointegrator 1 Complex
	Molecular Function	RNA Binding Protein Binding ATP Binding 3'-5' DNA Helicase Activity	Protease Binding Transcription Coactivator Activity Protein Binding Zinc Ion Binding Nuclear Receptor Binding Protein Kinase Binding Estrogen Receptor Binding Histone Acetyltransferase Binding Ubiquitin-like Protein Ligase Binding
	Biological Process	DNA Dealkylation Involved In DNA Repair Cell Population Proliferation DNA Duplex Unwinding	Regulation Of Transcription, DNA-templated Intracellular Estrogen Receptor Signaling Pathway Regulation Of Myoblast Differentiation Positive Regulation Of Transcription, DNA-templated Toxin Transport
Pathways		ALKBH3 mediated reversal of alkylation damage
Drugs
Diseases
GWAS		Economic and political preferences (immigration/crime) ( 22566634) Insomnia symptoms (never/rarely vs. sometimes/usually) ( 30804566) Insomnia symptoms (never/rarely vs. usually) ( 30804566) Menarche (age at onset) ( 25231870) Metabolite levels ( 23823483) Multiple system atrophy (pathologically confirmed) ( 27629089) Neurociticism ( 29500382) Neuroticism ( 29255261) Number of sexual partners ( 30643258) Putamen volume ( 29147026) Smoking initiation (ever regular vs never regular) ( 30679032) Smoking status (ever vs never smokers) ( 30643258) Sub-cortical grey matter volume ( 31530798)	Alzheimer's disease (late onset) ( 24162737) Neuroticism ( 29255261)
Interacting Genes		5 interacting genes: ASCC1 PTEN SKIL TRIP4 UBC	23 interacting genes: AR ASCC2 ASCC3 CREBBP EP300 ESR1 ESR2 GTF2A1 JUN NCOA1 NEK6 NFKB1 NR2F2 PAX9 PPARG RARA RELA RXRA SRF TBP THRB UBC XBP1
Entrez ID		10973	9325
HPRD ID		09980	05140
Ensembl ID		ENSG00000112249	ENSG00000103671
Uniprot IDs		B4DR60 Q8N3C0	Q15650
PDB IDs		6YXQ	2E5O
Enriched GO Terms of Interacting Partners?
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